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Autonomy Challenges in Epigenetic Risk-Stratified Cancer Screening: How Can Patient Decision Aids Support Informed Consent?
- Source :
- Journal of Personalized Medicine, Journal of Personalized Medicine, Vol 9, Iss 1, p 14 (2019), Journal of Personalized Medicine, 9(1):14. Multidisciplinary Digital Publishing Institute (MDPI)
- Publication Year :
- 2019
- Publisher :
- Multidisciplinary Digital Publishing Institute (MDPI), 2019.
-
Abstract
- Information of an individual's epigenome can be useful in cancer screening to enable personalised decision making on participation, treatment options and further screening strategies. However, adding this information might result in complex risk predictions on multiple diseases, unsolicited findings and information on (past) environmental exposure and behaviour. This complicates informed consent procedures and may impede autonomous decision-making. In this article we investigate and identify the specific features of epigenetic risk-stratified cancer screening that challenge the current informed consent doctrine. Subsequently we describe current and new informed consent models and the principle of respect for autonomy and argue for a specific informed consent model for epigenetic risk-stratified screening programmes. Next, we propose a framework that guides the development of Patient Decision Aids (PDAs) to support informed consent and promote autonomous choices in the specific context of epigenetic cancer screening programmes.
- Subjects :
- media_common.quotation_subject
Medicine (miscellaneous)
lcsh:Medicine
Context (language use)
Review
0603 philosophy, ethics and religion
03 medical and health sciences
risk prediction
SDG 3 - Good Health and Well-being
Informed consent
Cancer screening
Decision aids
patient decision aids
media_common
0303 health sciences
Medical education
epigenetics
patient autonomy
030305 genetics & heredity
lcsh:R
informed consent
Treatment options
06 humanities and the arts
Environmental exposure
Epigenome
3. Good health
cancer screening programmes
060301 applied ethics
Psychology
Autonomy
Subjects
Details
- ISSN :
- 20754426
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Personalized Medicine
- Accession number :
- edsair.doi.dedup.....2cbbb3561b06e707afe613876a5118b1