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Rare crystalline nephropathy leading to acute graft dysfunction: a case report
- Source :
- BMC Nephrology, BMC Nephrology, Vol 20, Iss 1, Pp 1-3 (2019)
- Publication Year :
- 2019
-
Abstract
- Background Adenine phosphoribosyl transferase (APRT) deficiency is a rare genetic form of kidney stones and/or kidney failure characterized by intratubular precipitation of 2,8 dihydroxyadenine crystals. Early diagnosis and prompt management can completely reverse the kidney injury. Case presentation 44 year old Indian male, renal transplant recipient got admitted with acute graft dysfunction. Graft biopsy showed light brown refractile intratubular crystals with surrounding giant cell reaction, consistent with APRT deficiency. Patient improved after receiving allopurinol and hydration. Conclusion APRT forms a reversible cause of crystalline nephropathy. High index of suspicion is required for the correct diagnosis as timely diagnosis has therapeutic implications.
- Subjects :
- Nephrology
Adult
Male
medicine.medical_specialty
Graft dysfunction
endocrine system
Antimetabolites
Allopurinol
Biopsy
Urology
Adenine Phosphoribosyltransferase
Case Report
APRT
lcsh:RC870-923
Nephropathy
Urolithiasis
Internal medicine
Medicine
Humans
Hydrotherapy
Kidney
medicine.diagnostic_test
business.industry
Adenine
Dihydroxyadenine
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Kidney Transplantation
medicine.anatomical_structure
Giant cell
Crystalline nephropathy
Kidney stones
Primary Graft Dysfunction
business
Crystallization
Metabolism, Inborn Errors
medicine.drug
Subjects
Details
- ISSN :
- 14712369
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC nephrology
- Accession number :
- edsair.doi.dedup.....2ca2051d1ae7530aaa65120e476565e9