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Structural Features of Apicomplexan Pore-Forming Proteins and Their Roles in Parasite Cell Traversal and Egress
- Source :
- Toxins, Toxins, Vol 9, Iss 9, p 265 (2017)
- Publication Year :
- 2017
- Publisher :
- MDPI, 2017.
-
Abstract
- Apicomplexan parasites cause diseases, including malaria and toxoplasmosis, in a range of hosts, including humans. These intracellular parasites utilize pore-forming proteins that disrupt host cell membranes to either traverse host cells while migrating through tissues or egress from the parasite-containing vacuole after replication. This review highlights recent insight gained from the newly available three-dimensional structures of several known or putative apicomplexan pore-forming proteins that contribute to cell traversal or egress. These new structural advances suggest that parasite pore-forming proteins use distinct mechanisms to disrupt host cell membranes at multiple steps in parasite life cycles. How proteolytic processing, secretion, environment, and the accessibility of lipid receptors regulate the membranolytic activities of such proteins is also discussed.
- Subjects :
- 0301 basic medicine
cell traversal
Pore Forming Cytotoxic Proteins
membrane disruption
Health, Toxicology and Mutagenesis
Cell
Protozoan Proteins
lcsh:Medicine
Vacuole
Review
Toxicology
Host-Parasite Interactions
Apicomplexa
03 medical and health sciences
Protein structure
medicine
Parasite hosting
Animals
Humans
Secretion
protein structure
Receptor
biology
Intracellular parasite
lcsh:R
regulation
biology.organism_classification
3. Good health
Cell biology
egress
030104 developmental biology
medicine.anatomical_structure
parasite
apicomplexan
pore-forming proteins
Subjects
Details
- Language :
- English
- ISSN :
- 20726651
- Volume :
- 9
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Toxins
- Accession number :
- edsair.doi.dedup.....2ca0dc2777f38e0ad14aacfa91ec310f