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Development and validation of a preoperative prognostic index independent of TNM stage in resected non-small cell lung cancer
- Source :
- BMC Pulmonary Medicine, BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- BioMed Central, 2017.
-
Abstract
- Background Previously reported prognostic tools for patients with resected non-small cell lung cancer (NSCLC) include factors found postoperatively, but not preoperatively. However, it would be important to predict patient prognosis before NSCLC resection. To suggest a novel preoperative prognostic tool, we evaluated the relationship of preoperative prognostic factors with the survival of patients with resected NSCLC. Methods We retrospectively reviewed the data of two independent cohorts of patients with completely resected NSCLC. To develop the prognostic index in one cohort, the overall survival (OS) was evaluated using the Cox proportional hazards model. We assessed the disease-free survival (DFS) and OS of three risk groups defined according to the prognostic index. Then, the prognostic index was validated in the other cohort. Results Seven independent risk factors for OS were selected: age ≥ 70 years, ever-smokers, vital capacity normal limit, non-usual interstitial pneumonia (UIP) pattern, and UIP pattern. Three risk groups were defined: low-risk (36.9%), intermediate-risk (54.0%), and high-risk (9.1%). In the derivation cohort, the 5-year DFS rate was 77.8%, 58.8%, and 22.6% (P
- Subjects :
- Oncology
Male
Multivariate analysis
Lung Neoplasms
Neutrophils
Vital Capacity
030204 cardiovascular system & hematology
0302 clinical medicine
Non-small cell lung cancer
Risk Factors
Carcinoma, Non-Small-Cell Lung
Overall survival
Stage (cooking)
Aged, 80 and over
Smoking
Age Factors
Middle Aged
Survival Rate
030220 oncology & carcinogenesis
Cohort
Preoperative Period
Female
Non small cell
Research Article
Pulmonary and Respiratory Medicine
Adult
medicine.medical_specialty
Disease-free survival
Curative resection
Risk Assessment
03 medical and health sciences
Young Adult
Predictive Value of Tests
Internal medicine
medicine
Humans
Derivation
Lymphocyte Count
Lung cancer
Pathological
Aged
Neoplasm Staging
Retrospective Studies
lcsh:RC705-779
Keratin-19
Proportional hazards model
business.industry
Preoperative prognostic factors
lcsh:Diseases of the respiratory system
medicine.disease
Idiopathic Pulmonary Fibrosis
Peptide Fragments
business
Subjects
Details
- Language :
- English
- ISSN :
- 14712466
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- BMC Pulmonary Medicine
- Accession number :
- edsair.doi.dedup.....2c9c75874df23ebe8f54702e2fd6c305