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Day 4 good morula embryo transfer provided compatible live birth rate with day 5 blastocyst embryo in fresh IVF/ET cycles
- Source :
- Taiwanese Journal of Obstetrics & Gynecology, Vol 57, Iss 1, Pp 52-57 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Objective Embryo transfers during cleavage stage (day 2 or day 3) and blastocyst stages (day 5 or day 6) are common in current daily practice in fresh IVF/ET cycles. Data regarding transferring day 4 embryos, morula/compact stage, is still restricted and the grading system is also inconsistent, as between IVF clinics. This study provided a new detailed classification system for morula/compact stage embryos and compared successes rates between day 4 and day 5 ET. Materials and methods This was a retrospective study. A review of medical records from January 1st, 2013, to December 31st 2015, performed for all conventional insemination and ICSI cycles with a GnRH-antagonist protocol at the Infertility Division of MacKay Memorial Hospital in Taipei City, Taiwan. Results There were 427 cycles included in our study, 107 in study group (day 4 MET) and 320 in control group (day 5 BET). Pregnancy rates and live birth rate were compatible, as between morula embryo transfer (MET) and blastocyst embryo transfer (BET). The implantation rate (36.3% vs. 39.6%, respectively, p = 0.500), clinical pregnancy rate (49.5% vs. 51.9%, respectively, p = 0.737), and live birth rate (42.1% vs. 45.6%, respectively, p = 0.574) were statistically insignificant between groups. The term birth rate was statistically higher in the MET group than in the BET group (95.7% vs. 79.5%, respectively, p = 0.006). When the clinical outcomes between day 4 good MET and day 5 good BET were compared, the results were compatible. The implantation rate (48.8% vs. 41.1%, respectively, p = 0.335), clinical pregnancy rate (55.0% vs. 53.2%, respectively, p = 0.867), and live birth rate (47.5% vs. 47.1%, respectively, p = 1.000) showed no significant difference. The term birth rate was also higher in day 4 good MET group than in day 5 good BET group (100% vs. 78.3%, respectively, p = 0.025). Conclusion In this study, we performed day 4 MET avoid BET on Sunday. The grading system we provided was more detailed for embryo selection and it was easier to remember. Our data showed that morula embryo transfer might be a flexible, easier and applicable method for embryo transfer in daily routine.
- Subjects :
- Adult
0301 basic medicine
Infertility
medicine.medical_specialty
Time Factors
Pregnancy Rate
Taiwan
Fertilization in Vitro
Insemination
Morula
lcsh:Gynecology and obstetrics
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
Live birth rate
Blastocyst
Birth Rate
lcsh:RG1-991
Retrospective Studies
Gynecology
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
Embryo
Embryo Transfer
medicine.disease
Embryo transfer
Morula embryo transfer
Day 4 embryo transfer
030104 developmental biology
medicine.anatomical_structure
IVF
embryonic structures
Term Birth
Female
Live birth
business
Live Birth
Subjects
Details
- ISSN :
- 10284559
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Taiwanese Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....2c8acd9440cc115adcc7182d1b121a7d