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Neurophysiological correlates of excitement in men with recent-onset psychosis
- Source :
- Psychiatria Danubina, Volume 30, Issue 1
- Publication Year :
- 2018
-
Abstract
- © Medicinska naklada, Zagreb, Croatia. Objective: Right frontal function, as indicated by the N200 component of the event-related potential during target detection, has previously been associated with excitement (excitement, impulsivity, hostility, uncooperativeness) in men with a long-term diagnosis of schizophrenia. The current study investigated excitement in relation to N200 in men who had recently experienced their first episode of psychosis. Subjects and methods: Twenty men who had recently suffered their first psychotic episode underwent a clinical interview and auditory oddball task. Results: Multiple linear regression analysis showed that 58% of the variance in the excitement symptom cluster was explained by a positive association with frontal midline N200 amplitude and an inverse association with right frontal N200 amplitude. The latter was not apparent in the initial correlation, suggesting suppression by the midline activity. These associations were not explained by drug use, medication or negative symptoms. However, the correlation between excitement and midline N200 was stronger in drug users, and that between right frontal N200 and excitement was stronger in nonusers. Conclusion: Findings support the independent contributions to excitement of mechanisms reflected in midline and right frontal N200 amplitude respectively during the early stages of psychosis. BIAL foundation
- Subjects :
- Adult
Male
Pleasure
Psychosis
medicine.medical_specialty
Adolescent
Statistics as Topic
recent-onset
Neurophysiology
Hostility
Electroencephalography
Audiology
Impulsivity
event-related potentials
03 medical and health sciences
Young Adult
0302 clinical medicine
Event-related potential
Interview, Psychological
medicine
Humans
psychosis
Young adult
N200
Psychiatry
Dominance, Cerebral
Evoked Potentials
drug use
First episode
medicine.diagnostic_test
General Medicine
medicine.disease
030227 psychiatry
Frontal Lobe
Psychiatry and Mental health
excitement
Impulsive Behavior
Schizophrenia
Schizophrenic Psychology
medicine.symptom
Psychology
Arousal
030217 neurology & neurosurgery
Diagnosis of schizophrenia
Subjects
Details
- Language :
- English
- ISSN :
- 03535053
- Database :
- OpenAIRE
- Journal :
- Psychiatria Danubina, Volume 30, Issue 1
- Accession number :
- edsair.doi.dedup.....2c872d76a395aceb870686581d031cab