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Diagnostic Value of (18)F-Fluorodeoxyglucose Positron Emission Tomography Computed Tomography in Prosthetic Pulmonary Valve Infective Endocarditis
- Source :
- JACC: Cardiovascular Imaging, JACC: Cardiovascular Imaging, 2022, 15 (2), pp.299-308. ⟨10.1016/j.jcmg.2021.07.015⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- International audience; OBJECTIVES: The aim of this study was to assess the diagnostic performances of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) in congenital heart disease (CHD) patients with pulmonary prosthetic valve or conduit endocarditis (PPVE) suspicion. BACKGROUND: PPVE is a major issue in the growing CHD population. Diagnosis is challenging, and usual imaging tools are not always efficient or validated in this specific population. Particularly, the diagnostic yield of (18)F-FDG PET/CT remains poorly studied in PPVE. METHODS: A retrospective multicenter study was conducted in 8 French tertiary centers. Children and adult CHD patients who underwent (18)F-FDG PET/CT in the setting of PPVE suspicion between January 2010 and May 2020 were included. The cases were initially classified as definite, possible, or rejected PPVE regarding the modified Duke criteria and finally by the Endocarditis Team consensus. The result of (18)F-FDG PET/CT had been compared with final diagnosis consensus used as gold-standard in our study. RESULTS: A total of 66 cases of PPVE suspicion involving 59 patients (median age 23 years, 73% men) were included. Sensitivity, specificity, positive predictive value, and negative predictive value of (18)F-FDG PET/CT in PPVE suspicion were respectively: 79.1% (95% CI: 68.4%-91.4%), 72.7% (95% CI: 60.4%-85.0%), 91.9% (95% CI: 79.6%-100.0%), and 47.1% (95% CI: 34.8%-59.4%). (18)F-FDG PET/CT findings would help to correctly reclassify 57% (4 of 7) of possible PPVE to definite PPVE. CONCLUSIONS: Using (18)F-FDG PET/CT improves the diagnostic accuracy of the Duke criteria in CHD patients with suspected PPVE. Its high positive predictive value could be helpful in routine to shorten diagnosis and treatment delays and improve clinical outcomes.
- Subjects :
- medicine.diagnostic_test
business.industry
Pulmonary valve
18F-FDG PET/CT
Computed tomography
medicine.disease
Fluorodeoxyglucose positron emission tomography
medicine.anatomical_structure
Positron emission tomography
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Infective endocarditis
medicine
Radiology, Nuclear Medicine and imaging
Fdg pet ct
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Congenital heart disease
Subjects
Details
- Language :
- English
- ISSN :
- 1936878X and 18767591
- Database :
- OpenAIRE
- Journal :
- JACC: Cardiovascular Imaging, JACC: Cardiovascular Imaging, 2022, 15 (2), pp.299-308. ⟨10.1016/j.jcmg.2021.07.015⟩
- Accession number :
- edsair.doi.dedup.....2c7fe8c0435b09856ca0c0689fe18cf2