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Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease
- Source :
- Alzheimer's Research & Therapy, Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-15 (2019), Alzheimer's Research and Therapy, Alzheimer's Research and Therapy, BioMed Central, 2019, 11 (1), pp.34. ⟨10.1186/s13195-019-0485-0⟩, Alzheimer's Research and Therapy, 2019, 11 (1), pp.34. ⟨10.1186/s13195-019-0485-0⟩
- Publication Year :
- 2019
- Publisher :
- BioMed Central, 2019.
-
Abstract
- International audience; The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ42), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau181) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzheimer's Disease (AD). In an effort to improve the accuracy of an AD diagnosis, it is important to be able to distinguish between AD and other types of dementia (non-AD). The concentration ratio of Aβ42 to Aβ40 (Aβ42/40 Ratio) has been suggested to be superior to the concentration of Aβ42 alone when identifying patients with AD. This article reviews the available evidence on the use of the CSF Aβ42/40 ratio in the diagnosis of AD. Based on the body of evidence presented herein, it is the conclusion of the current working group that the CSF Aβ42/40 ratio, rather than the absolute value of CSF Aβ42, should be used when analysing CSF AD biomarkers to improve the percentage of appropriately diagnosed patients.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Neurology
Amyloid β
Cognitive Neuroscience
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Diagnostic accuracy
Disease
Review
Aβ 42/40 ratio
Alzheimer's Disease
lcsh:RC346-429
lcsh:RC321-571
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Medizinische Fakultät
Alzheimer Disease
Internal medicine
medicine
Dementia
Humans
ddc:610
Alzheimer’s Disease
Cognitive impairment
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Biochemical markers
lcsh:Neurology. Diseases of the nervous system
Cerebrospinal Fluid
Amyloid beta-Peptides
[SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
business.industry
[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
medicine.disease
Peptide Fragments
030104 developmental biology
Aβ42/40 ratio
Neurology (clinical)
business
030217 neurology & neurosurgery
Amyloidβ Peptides
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 17589193
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Alzheimer's Research & Therapy
- Accession number :
- edsair.doi.dedup.....2c709a9e5df0ee5db59fbd9582c6ab2b