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Impaired Retinal Function in Young Labrador Retriever Dogs Heterozygous for Late Onset Rod-Cone Degeneration
- Source :
- Vision Research. (3):365-370
- Publisher :
- Elsevier Science Ltd.
-
Abstract
- Xenon-flash d.c.-electroretinograms were recorded from dark adapted, rod-cone degenerate homozygote affected (n = 6), heterozygote carrier (n = 3) and control retinas (n = 4) at 3 and 4 months of age, starting at 0.6 log units below control PII threshold. One log unit higher stimuli were necessary to evoke PII in heterozygote and affected retinas compared to controls. Unique to the heterozygotes, double peaked PII responses that were evoked by −2 log relative units intensity stimulation were significantly (P = 0.028) lower in amplitude than those of controls. PII amplitudes of homozygotes were significantly (P = 0.005) lower in amplitude than those of controls at both ages examined in response to −2 and 0 log relative intensity stimulation. No differences were found in scotopic threshold response amplitudes or times to peak between the three groups. Homozygote affected PII times to peak were significantly (P = 0.005) shorter in relation to controls at −2 log units. Findings suggest that heterozygotes exhibit an impaired retinal function which can be demonstrated at 3 and 4 months in this mutant. Copyright © 1996 Elsevier Science Ltd
- Subjects :
- Heterozygote
medicine.medical_specialty
Dog model
Dark Adaptation
Late onset
Stimulation
Biology
03 medical and health sciences
Dogs
0302 clinical medicine
Optics
Retinal Diseases
Internal medicine
Electroretinography
medicine
Carnivora
Animals
Photoreceptor Cells
Dog Diseases
Scotopic vision
Rod-cone
medicine.diagnostic_test
business.industry
Fissipedia
fungi
Heterozygote advantage
biology.organism_classification
Sensory Systems
Intensity (physics)
Ophthalmology
Endocrinology
Heterozygous
Electroretinography (ERG)
030221 ophthalmology & optometry
Degeneration
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 00426989
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Vision Research
- Accession number :
- edsair.doi.dedup.....2c64c68d1e47ec7d1a4610fb761312c8
- Full Text :
- https://doi.org/10.1016/S0042-6989(96)00123-X