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Normal and osteoporotic human osteoblast behaviour after 1,25-dihydroxy-vitamin D(3) stimulation
- Source :
- Rheumatology international. 29(6)
- Publication Year :
- 2008
-
Abstract
- In order to examine the effects of vitamin D on osteoblast function and to evaluate if osteoporotic and normal osteoblasts show a different behaviour in response to vitamin D, this report investigates the changes in osteocalcin production, after 1,25-dihydroxy-vitamin D(3) stimulation of cultured osteoblasts derived from osteoporotic patients. Our results indicate an inadequate osteoblastic function in osteoporosis and demostrate that 1,25-dihydroxy-vitamin D(3) can stimulate the metabolic activity of human osteoblasts in vitro. Considering that osteoporotic bone samples were representative of senile osteoporosis, our results may indicate a different metabolic phenotype in osteoporotic osteoblasts compared with normal osteoblasts. The increased osteocalcin production after 1,25-dihydroxy-vitamin D(3) stimulation of osteoporotic osteoblasts suggests a reduced, but not absent, anabolic function in senile osteoporotic osteoblasts. The results of this study confirm the validity of vitamin D(3) to treat senile osteoporosis and suggest the need of higher vitamin D(3) intake in senile osteoporotic patients than in younger subjects.
- Subjects :
- musculoskeletal diseases
Vitamin
Adult
Male
medicine.medical_specialty
Senile osteoporosis
Time Factors
Anabolism
Cell Survival
Immunology
Osteoporosis
Osteocalcin
Stimulation
Cell Separation
chemistry.chemical_compound
Rheumatology
Internal medicine
medicine
Vitamin D and neurology
Immunology and Allergy
Humans
Cell Lineage
Vitamin D
Coloring Agents
Cells, Cultured
Aged
Osteoblasts
biology
business.industry
Osteoblast
Trypan Blue
Middle Aged
medicine.disease
Alkaline Phosphatase
medicine.anatomical_structure
Endocrinology
chemistry
Case-Control Studies
biology.protein
Female
business
Subjects
Details
- ISSN :
- 1437160X
- Volume :
- 29
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Rheumatology international
- Accession number :
- edsair.doi.dedup.....2c63dffc61736dc12b971991f63d0e7c