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Invasive Pneumococcal Disease in UK Children1 Year of Age in the Post-13-Valent Pneumococcal Conjugate Vaccine Era: What Are the Risks Now?
Invasive Pneumococcal Disease in UK Children1 Year of Age in the Post-13-Valent Pneumococcal Conjugate Vaccine Era: What Are the Risks Now?
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 69(1)
- Publication Year :
- 2018
-
Abstract
- Background Invasive pneumococcal disease (IPD) has declined significantly since the introduction of pneumococcal conjugate vaccines (PCVs). It is not known whether certain infant populations remain at higher risk of IPD in countries with established 13-valent PCV (PCV13) programs. We aimed to describe the epidemiology, clinical characteristics, serotype distribution, and outcomes of IPD in infants, and to estimate the relative risk of PCV13-type, non-PCV13-type, and overall IPD in premature infants compared to term infants during a 4-year period after the PCV13 program was established. Methods This was a prospective, enhanced national surveillance of laboratory-confirmed IPD in England in infants aged
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Male
medicine.medical_specialty
Pediatrics
030106 microbiology
Rate ratio
Serogroup
Pneumococcal conjugate vaccine
Pneumococcal Infections
Pneumococcal Vaccines
03 medical and health sciences
0302 clinical medicine
Risk Factors
Epidemiology
Case fatality rate
medicine
Humans
030212 general & internal medicine
Prospective Studies
business.industry
Immunization Programs
Incidence (epidemiology)
Incidence
Infant, Newborn
Pneumococcal 7-Valent Conjugate Vaccine
Infant
bacterial infections and mycoses
Confidence interval
Infectious Diseases
England
Relative risk
Epidemiological Monitoring
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15376591
- Volume :
- 69
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....2c5e4f1c568d79cc96b0096404fda8fa