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Invasive Pneumococcal Disease in UK Children1 Year of Age in the Post-13-Valent Pneumococcal Conjugate Vaccine Era: What Are the Risks Now?

Invasive Pneumococcal Disease in UK Children1 Year of Age in the Post-13-Valent Pneumococcal Conjugate Vaccine Era: What Are the Risks Now?

Authors :
Mary Ramsay
Ashley Makwana
Sarah A. Collins
Paul T. Heath
Alison Kent
Carmen L. Sheppard
Norman K. Fry
Shamez N Ladhani
Source :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 69(1)
Publication Year :
2018

Abstract

Background Invasive pneumococcal disease (IPD) has declined significantly since the introduction of pneumococcal conjugate vaccines (PCVs). It is not known whether certain infant populations remain at higher risk of IPD in countries with established 13-valent PCV (PCV13) programs. We aimed to describe the epidemiology, clinical characteristics, serotype distribution, and outcomes of IPD in infants, and to estimate the relative risk of PCV13-type, non-PCV13-type, and overall IPD in premature infants compared to term infants during a 4-year period after the PCV13 program was established. Methods This was a prospective, enhanced national surveillance of laboratory-confirmed IPD in England in infants aged

Details

ISSN :
15376591
Volume :
69
Issue :
1
Database :
OpenAIRE
Journal :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Accession number :
edsair.doi.dedup.....2c5e4f1c568d79cc96b0096404fda8fa