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Effects of Foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
- Source :
- Biotechnic & Histochemistry. 92:274-282
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and limonene were applied topically to the wounds once daily, separately or together, for 10 days. Tissue sections from the wounds were evaluated for histopathology. The healing potential was assessed by comparison to an untreated control group and an olive oil treated sham group. We scored wound healing based on epidermal regeneration, granulation tissue thickness and angiogenesis. After day 6, wound contraction with limonene was significantly better than for the control group. Ten days after treatment, a significant increase was observed in wound contraction and re-epithelialization in both fenchone and limonene oil treated groups compared to the sham group. Groups treated with fenchone and with fenchone + limonene scored significantly higher than the control group, but the difference was not statistically significant compared to the olive oil treated group. Our findings support the beneficial effects of fenchone and limonene for augmenting wound healing. The anti-inflammatory and antimicrobial activities of fenchone and limonene oil increased collagen synthesis and decreased the number of inflammatory cells during wound healing and may be useful for treating skin wounds.
- Subjects :
- Male
medicine.medical_specialty
Histology
Foeniculum
Pharmacology
01 natural sciences
law.invention
Rats, Sprague-Dawley
Terpene
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Microscopy, Electron, Transmission
law
Cyclohexenes
Oils, Volatile
medicine
Animals
Foeniculum Vulgare
Olive Oil
Essential oil
Skin
Wound Healing
Limonene
Camphanes
integumentary system
biology
Plant Extracts
Terpenes
Granulation tissue
Fenchone
General Medicine
biology.organism_classification
Immunohistochemistry
Norbornanes
Essential Oil
Rats
0104 chemical sciences
Surgery
010404 medicinal & biomolecular chemistry
Medical Laboratory Technology
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Histopathology
Wound healing
Subjects
Details
- ISSN :
- 14737760 and 10520295
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Biotechnic & Histochemistry
- Accession number :
- edsair.doi.dedup.....2c5decb78d428fde988083be1bfbc547