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Baseline Serum Lactate Dehydrogenase Levels for Patients Treated With Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma: A Predictor of Poor Prognosis and Subsequent Liver Metastasis
- Source :
- International Journal of Radiation Oncology*Biology*Physics. 82:e359-e365
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Purpose To evaluate the prognostic value of baseline serum lactate dehydrogenase (LDH) levels in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). Methods and Materials Cases of NPC ( n = 465) that involved treatment with IMRT with or without chemotherapy were retrospectively analyzed. Results The mean (±SD) and median baseline serum LDH levels for this cohort were 172.77 ± 2.28 and 164.00 IU/L, respectively. Levels of LDH were significantly elevated in patients with locoregionally advanced disease ( p = 0.016). Elevated LDH levels were identified as a prognostic factor for rates of overall survival (OS), disease-free survival (DFS), and distant metastasis-free survival (DMFS), with p values p p = 0.004, and p = 0.003, respectively, in the multivariate analysis. Correspondingly, the prognostic impact of patient LDH levels was found to be statistically significant for rates of OS, DFS, and DMFS ( p = 0.028, 0.024, and 0.020, respectively). For patients who experienced subsequent liver failure after treatment, markedly higher pretreatment serum LDH levels were detected compared with patients experiencing distant metastasis events at other sites ( p = 0.032). Conclusions Elevated baseline LDH levels are associated with clinically advanced disease and are a poor prognosticator for OS, DFS, and DMFS for NPC patients. These results suggest that elevated serum levels of LDH should be considered when evaluating treatment options.
- Subjects :
- Male
Oncology
China
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Gastroenterology
Disease-Free Survival
Metastasis
chemistry.chemical_compound
Lactate dehydrogenase
Internal medicine
Biomarkers, Tumor
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Neoplasm Staging
Retrospective Studies
Analysis of Variance
Chemotherapy
Radiation
L-Lactate Dehydrogenase
business.industry
Carcinoma
Liver Neoplasms
Nasopharyngeal Neoplasms
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Radiation therapy
chemistry
Nasopharyngeal carcinoma
Cohort
Female
Radiotherapy, Intensity-Modulated
business
Serum lactate dehydrogenase
Subjects
Details
- ISSN :
- 03603016
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- International Journal of Radiation Oncology*Biology*Physics
- Accession number :
- edsair.doi.dedup.....2c4b28f664e66246e63a1ed3d7a45677