Figure S1, S2, S3 from Genomic and Epigenomic Signatures in Ovarian Cancer Associated with Resensitization to Platinum Drugs

Figure S1. (A) Predicted cancer/stromal signatures in TCGA and our data. (B) Correlation between NMF and ESTIMATION estimated cancer cell purity in TCGA OV data. (C,D) Predicted relative proportion of cancer/stromal cell in our and TCGA data. Figure S2. Full list of pathways enriched by differentially expressed genes induced by guadecitabine. Figure S3. A-D. Spearman correlation between the beta values of 24 CpG sites within the promoters of 19 genes significantly demethylated in ascites samples and predicted proportions of B cells (A), T cells (B), NK cells (C), and total cells (D). E-H. Spearman correlation between the beta values of 352 CpG sites within the promoters of 94 genes significantly demethylated in tumor samples and predicted proportion of B cells (E), T cells (F), NK cells (G), and total cells (H). Complete sets of correlation coefficients are provided in Supplementary Table 8. X axis corresponds to Spearman correlation coefficients.