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Diagnosis of human immunodeficiency virus associated disseminated intravascular coagulation
- Source :
- PLoS ONE, Vol 17, Iss 1, p e0262306 (2022), PLoS ONE, PLoS ONE, Vol 17, Iss 1 (2022)
- Publication Year :
- 2022
- Publisher :
- Public Library of Science (PLoS), 2022.
-
Abstract
- Introduction Disseminated intravascular Coagulation (DIC) is a thrombotic microangiopathy which may complicate a number of severe disease processes including sepsis. Development of microvascular thromboses results in consumption of coagulation factors and platelets and ultimate bleeding. Patients with HIV infection (PWH) often present with baseline dysregulation of the coagulation system which may increase severity and derangement of DIC presentation. Previously, we have shown that HIV is a significant risk factor for development of DIC. Methodology We conducted a retrospective record review of all DIC screens submitted to our tertiary coagulation laboratory in Johannesburg, South Africa, over a one year period and compared the laboratory presentation of DIC in PWH with presentation of DIC in patients without HIV infection. Results Over the year, 246 patients fulfilled the International Society of Thrombosis and Haemostasis (ISTH) diagnostic criteria for DIC– 108 were confirmed HIV-infected and 77 were confirmed uninfected. PWH and DIC presented at a significantly earlier age (41 vs 46 years respectively, p9/l) were significantly lower in PWH. PWH also showed significant synthetic liver dysfunction and higher background inflammation. Conclusion PWH who fulfil the diagnostic criteria for DIC show significantly more dysregulation of the haemostatic system. This may reflect baseline abnormalities including endothelial dysfunction in the context of inflammation and liver dysfunction.
- Subjects :
- RNA viruses
Male
Physiology
HIV Infections
Cardiovascular Medicine
Pathology and Laboratory Medicine
Biochemistry
Vascular Medicine
Severity of Illness Index
Tertiary Care Centers
White Blood Cells
South Africa
Immunodeficiency Viruses
Animal Cells
hemic and lymphatic diseases
Signs and symptoms
Multidisciplinary
T Cells
Hematology
Viral Load
Middle Aged
Body Fluids
Blood
Medical Microbiology
Cardiovascular Diseases
Viral Pathogens
Viruses
Infectious diseases
Medicine
HIV clinical manifestations
Female
Blood Coagulation Tests
Anatomy
Cellular Types
Pathogens
Coagulation Factors
Research Article
circulatory and respiratory physiology
Medical conditions
Platelets
Adult
Blood Platelets
Immune Cells
Science
Immunology
Cardiology
Viral diseases
Microbiology
Virology
Retroviruses
Humans
Microbial Pathogens
Blood Coagulation
Retrospective Studies
Medicine and health sciences
Blood Cells
Coagulation Disorders
Lentivirus
Organisms
Biology and Life Sciences
HIV
Proteins
Fibrinogen
Thrombosis
Cell Biology
Disseminated Intravascular Coagulation
Clinical medicine
Prothrombin Time
Viral Transmission and Infection
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....2c3cf76c357a126c12b5218c3953124d