Back to Search
Start Over
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
- Source :
- Smits, K M, Benhamou, S, Garte, S, Weijenberg, M P, Alamanos, Y, Ambrosone, C, Autrup, H, Autrup, J L, Baranova, H, Bathum, L, Boffetta, P, Bouchardy, C, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, M L, Coutelle, C, Daly, A K, Muzi, G, Dolzan, V, Duzhak, T G, Farker, K, Golka, K, Haugen, A, Hein, D W, Hildesheim, A, Hirvonen, A, Hsieh, L L, Ingelman-Sundberg, M, Kalina, I, Kang, D, Katoh, T, Kihara, M, Ono-Kihara, M, Kim, H, Kiyohara, C, Kremers, P, Lazarus, P, Le Marchand, L, Lechner, M C, London, S, Manni, J J, Maugard, C M, Morgan, G J, Morita, S, Nazar-Stewart, V, Kristensen, V N, Oda, Y, Parl, F F, Peters, W H, Ranung, A, Rebbeck, T, Pinto, L F, Risch, A, Romkes, M, Salagovic, J, Schoket, B, Seidegard, J, Shields, P G, Sim, E, Sinnet, D, Strange, R C, Stucker, I, Sugimura, H, To-Figueras, J, Vineis, P, Yu, M C, Zheng, W, Pedotti, P & Taioli, E 2004, ' Association of metabolic gene polymorphisms with tobacco consumption in healthy controls ', International Journal of Cancer, vol. 110, no. 2, pp. 266-270 ., Smits, K M, Benhamon, S, Garte, S, Weijenberg, M P, Almanos, Y, Ambrosone, C, Autrup, H, Autrup, J L, Baranova, H, Bathum, L, Boffetta, P, Bouchardy, C, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, M L, Coutelle, C, Daly, A K, Muzi, G, Dolzan, V, Duzhak, T G, Farker, K, Golka, K, Haugen, A, Hein, D W, Hildesheim, A, Hirvonen, A, Hsieh, L L, Ingelman-Sundberg, M, Kalina, I, Kang, D, Katoh, T, Kihara, M, Ono-Kihara, M, Kim, H, Kiyohara, C, Kremers, P, Lazarus, P, Le Marchand, L, Lechner, M C, London, S, Manni, J J, Maugard, C M, Morgan, G J, Morita, S, Nazar-Stewart, V, Kristensen, V N, Oda, Y, Parl, F F, Peters, W H M, Rannug, A, Rebbeck, T, Pinto, L F R, Risch, A, Romkes, M, Salagovic, J, Schoket, B, Seidegard, J, Shields, P G, Sim, E, Sinnett, D, Strange, R C, Stucker, I, Sugimura, H, To-Figueras, J, Vineis, P, Yu, M C, Zheng, W, Pedotti, P & Taioli, E 2004, ' Association of metabolic gene polymorphisms with tobacco consumption in healthy controls ', International Journal of Cancer, vol. 110, no. 2, pp. 266-270 ., International Journal of Cancer, 110(2), 266-270. Wiley, International Journal of Cancer, 110, 266-70, International Journal of Cancer, 110, 2, pp. 266-70
- Publication Year :
- 2004
-
Abstract
- Contains fulltext : 58545.pdf (Publisher’s version ) (Closed access) Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.
- Subjects :
- Cancer Research
Arylamine N-Acetyltransferase
Association of metabolic gene polymorphisms with tobacco
Biology
Isozyme
Tobacco smoke
03 medical and health sciences
0302 clinical medicine
Polymorphism (computer science)
Genotype
Genetic predisposition
Humans
Genetic Predisposition to Disease
Genetic variability
Gene
Carcinogen
Molecular diagnosis, prognosis and monitoring [UMCN 1.2]
030304 developmental biology
Glutathione Transferase
Genetics
0303 health sciences
Polymorphism, Genetic
Smoking
3. Good health
Isoenzymes
Oncology
Glutathione S-Transferase pi
030220 oncology & carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 00207136
- Database :
- OpenAIRE
- Journal :
- Smits, K M, Benhamou, S, Garte, S, Weijenberg, M P, Alamanos, Y, Ambrosone, C, Autrup, H, Autrup, J L, Baranova, H, Bathum, L, Boffetta, P, Bouchardy, C, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, M L, Coutelle, C, Daly, A K, Muzi, G, Dolzan, V, Duzhak, T G, Farker, K, Golka, K, Haugen, A, Hein, D W, Hildesheim, A, Hirvonen, A, Hsieh, L L, Ingelman-Sundberg, M, Kalina, I, Kang, D, Katoh, T, Kihara, M, Ono-Kihara, M, Kim, H, Kiyohara, C, Kremers, P, Lazarus, P, Le Marchand, L, Lechner, M C, London, S, Manni, J J, Maugard, C M, Morgan, G J, Morita, S, Nazar-Stewart, V, Kristensen, V N, Oda, Y, Parl, F F, Peters, W H, Ranung, A, Rebbeck, T, Pinto, L F, Risch, A, Romkes, M, Salagovic, J, Schoket, B, Seidegard, J, Shields, P G, Sim, E, Sinnet, D, Strange, R C, Stucker, I, Sugimura, H, To-Figueras, J, Vineis, P, Yu, M C, Zheng, W, Pedotti, P & Taioli, E 2004, ' Association of metabolic gene polymorphisms with tobacco consumption in healthy controls ', International Journal of Cancer, vol. 110, no. 2, pp. 266-270 ., Smits, K M, Benhamon, S, Garte, S, Weijenberg, M P, Almanos, Y, Ambrosone, C, Autrup, H, Autrup, J L, Baranova, H, Bathum, L, Boffetta, P, Bouchardy, C, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, M L, Coutelle, C, Daly, A K, Muzi, G, Dolzan, V, Duzhak, T G, Farker, K, Golka, K, Haugen, A, Hein, D W, Hildesheim, A, Hirvonen, A, Hsieh, L L, Ingelman-Sundberg, M, Kalina, I, Kang, D, Katoh, T, Kihara, M, Ono-Kihara, M, Kim, H, Kiyohara, C, Kremers, P, Lazarus, P, Le Marchand, L, Lechner, M C, London, S, Manni, J J, Maugard, C M, Morgan, G J, Morita, S, Nazar-Stewart, V, Kristensen, V N, Oda, Y, Parl, F F, Peters, W H M, Rannug, A, Rebbeck, T, Pinto, L F R, Risch, A, Romkes, M, Salagovic, J, Schoket, B, Seidegard, J, Shields, P G, Sim, E, Sinnett, D, Strange, R C, Stucker, I, Sugimura, H, To-Figueras, J, Vineis, P, Yu, M C, Zheng, W, Pedotti, P & Taioli, E 2004, ' Association of metabolic gene polymorphisms with tobacco consumption in healthy controls ', International Journal of Cancer, vol. 110, no. 2, pp. 266-270 ., International Journal of Cancer, 110(2), 266-270. Wiley, International Journal of Cancer, 110, 266-70, International Journal of Cancer, 110, 2, pp. 266-70
- Accession number :
- edsair.doi.dedup.....2c30350a89396fac6eb65ca88edb1f8d