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Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report
- Source :
- Sarcoma, Vol 2015 (2015), Sarcoma
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Purpose. To associate baseline patient characteristics and relapse across consecutive COG studies.Methods. We analyzed risk factors for LESFT patients in three randomized COG trials. We evaluated age at enrollment, primary site, gender, tumor size, and treatment (as randomized). We estimated event-free survival (EFS, Kaplan-Meier) and compared risk across groups (log-rank test). Characteristics were assessed by proportional hazards regression with the characteristic of interest as the only component. Confidence intervals (CI) for RR were derived. Factors related to outcome at level 0.05 were included in a multivariate regression model.Results. Between 12/1988 and 8/2005, 1444 patients were enrolled and data current to 2001, 2004, or 2008 were used. Patients were with a median age of 12 years (0–45), 55% male and 88% Caucasian. The 5-year EFS was 68.3% ± 1.3%. In univariate analysis age, treatment, and tumor location were identified for inclusion in the multivariate model, and all remained significant (p< 0.01). Since tumor size was not collected in the last study, the other two were reanalyzed. This model identified age, treatment, tumor location, and tumor size as significant predictors.Conclusion. Age > 18 years, pelvic tumor, size > 8 cms, and chemotherapy without ifosfamide/etoposide significantly predict worse outcome. AEWS0031 isNCT00006734, INT0091 and INT0054 designed before 1993 (unregistered).
- Subjects :
- Oncology
Pediatric Research Initiative
medicine.medical_specialty
Multivariate statistics
Article Subject
medicine.medical_treatment
Clinical Trials and Supportive Activities
Clinical Sciences
Oncology and Carcinogenesis
lcsh:RC254-282
03 medical and health sciences
Rare Diseases
0302 clinical medicine
Cog
Clinical Research
Internal medicine
medicine
Radiology, Nuclear Medicine and imaging
Oncology & Carcinogenesis
030212 general & internal medicine
10. No inequality
Etoposide
Cancer
Pediatric
Chemotherapy
Univariate analysis
Ifosfamide
business.industry
Evaluation of treatments and therapeutic interventions
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Confidence interval
3. Good health
6.1 Pharmaceuticals
030220 oncology & carcinogenesis
Pelvic tumor
business
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 13691643, 1357714X, and 00006734
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- Sarcoma
- Accession number :
- edsair.doi.dedup.....2c2a365ce274133f975691f6e0977b14
- Full Text :
- https://doi.org/10.1155/2015/927123