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mRNA profiling identifies low levels of phosphatases dual‐specific phosphatase‐7 (DUSP7) and cell division cycle‐25B (CDC25B) in patients with early arthritis
- Source :
- Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid
- Publication Year :
- 2017
-
Abstract
- Summary Phosphotyrosine phosphatases (PTPs) control phosphorylation levels and, consequently, regulate the output of intracellular signalling networks in health and disease. Despite the high number of PTPs expressed in CD4 T cells and their involvement in autoimmunity, information about the expression profile of PTPs in these cells has not been obtained in patients diagnosed with autoimmune diseases. Here, we compare the expression profile of PTPs in CD4 T cells of healthy volunteers and patients submitted to an early arthritis clinic, due to suspicion of rheumatoid arthritis, an autoimmune disease mediated by CD4 T cells. We found lower transcript levels of the mitogen-activated protein kinase (MAPK) phosphatase dual-specific phosphatase-7 (DUSP7) and the cell division cycle-25B (CDC25B) in T cells of patients. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of the disease. Low levels of CDC25B might contribute to the progression of the autoimmune arthritis and/or might be consequence of the inflammatory environment in the active disease. The possible role of DUSP7 and CDC25B as biomarkers of the disease in clinical protocols is discussed.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
Adult
CD4-Positive T-Lymphocytes
Male
Immunology
Phosphatase
CD4 T cells
PTPs
medicine.disease_cause
early arthritis
Autoimmunity
Autoimmune Diseases
03 medical and health sciences
Immunology and Allergy
Medicine
Rheumatoid factor
Humans
cdc25 Phosphatases
Prospective Studies
RNA, Messenger
Phosphorylation
Protein kinase A
Aged
Autoimmune disease
biology
business.industry
Arthritis
Original Articles
Middle Aged
medicine.disease
CDC25B
030104 developmental biology
DUSP7
Spain
Rheumatoid arthritis
biology.protein
Cancer research
Dual-Specificity Phosphatases
Female
Antibody
Corrigendum
business
Biomarkers
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid
- Accession number :
- edsair.doi.dedup.....2c29344609b1782b78e982755fbfb904