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Alterations in Nucleocytoplasmic Localization of the Methionine Cycle Induced by Oxidative Stress During Liver Disease

Authors :
Dolores Pérez-Sala
Oscar H. Martínez-Costa
Juan J. Aragón
María A. Pajares
Ministerio de Economía y Competitividad (España)
Pérez-Sala, Dolores
Martínez-Costa, Oscar H.
Pajares, María A.
Pérez-Sala, Dolores [0000-0003-0600-665X]
Martínez-Costa, Oscar H. [0000-0003-4893-2205]
Pajares, María A. [0000-0002-4714-9051]
Source :
Digital.CSIC. Repositorio Institucional del CSIC, instname
Publication Year :
2018
Publisher :
Elsevier, 2018.

Abstract

21 p.-5 fig.-2 tab. (Chapter 3)<br />Homeostasis of the main cellular methyl donor, S-adenosylmethionine, depends on the methionine cycle, which is at the crossroads of metabolic pathways involved in the synthesis and regulation of a large variety of compounds and processes. Impairment of the methionine cycle is detected in a vast majority of liver diseases that concur with oxidative stress. The complex regulation of the pathway is exerted from transcriptional to protein oligomerization and activity levels, subcellular distribution being recently added to the play. Oxidative stress performs a role at all of these regulatory levels either directly (e.g., eliciting protein modifications) or indirectly (e.g., decreasing recycling of vitamin B12). Therefore, the interest in deciphering the mechanisms through which medical interventions could revert methionine cycle impairment, contributing to liver disease treatment. In this line, the control of subcellular distribution has emerged as a putative target for new and existent antioxidants, their evaluation requiring a large research effort.<br />Work carried out in the author’s laboratories was supported by grants of the Ministerio de Economía y Competitividad (BFU2009-08977 to MAP; SAF2012-36519 and SAF2015-68590-R to DPS)

Details

ISSN :
20090897
Database :
OpenAIRE
Journal :
Digital.CSIC. Repositorio Institucional del CSIC, instname
Accession number :
edsair.doi.dedup.....2c28e7ce9c51eace6507074ac4e93242
Full Text :
https://doi.org/10.1016/b978-0-12-803951-9.00003-3