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Alterations in Nucleocytoplasmic Localization of the Methionine Cycle Induced by Oxidative Stress During Liver Disease
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- 21 p.-5 fig.-2 tab. (Chapter 3)<br />Homeostasis of the main cellular methyl donor, S-adenosylmethionine, depends on the methionine cycle, which is at the crossroads of metabolic pathways involved in the synthesis and regulation of a large variety of compounds and processes. Impairment of the methionine cycle is detected in a vast majority of liver diseases that concur with oxidative stress. The complex regulation of the pathway is exerted from transcriptional to protein oligomerization and activity levels, subcellular distribution being recently added to the play. Oxidative stress performs a role at all of these regulatory levels either directly (e.g., eliciting protein modifications) or indirectly (e.g., decreasing recycling of vitamin B12). Therefore, the interest in deciphering the mechanisms through which medical interventions could revert methionine cycle impairment, contributing to liver disease treatment. In this line, the control of subcellular distribution has emerged as a putative target for new and existent antioxidants, their evaluation requiring a large research effort.<br />Work carried out in the author’s laboratories was supported by grants of the Ministerio de Economía y Competitividad (BFU2009-08977 to MAP; SAF2012-36519 and SAF2015-68590-R to DPS)
- Subjects :
- 0301 basic medicine
Transsulfuration
medicine.disease_cause
Methylation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Acute liver injury
medicine
Protein oligomerization
S-adenosylmethionine
Methionine
Subcellular localization
Methionine metabolism
Glutathione
One-carbon metabolism
Cell biology
Metabolic pathway
030104 developmental biology
chemistry
Hepatic disease
030220 oncology & carcinogenesis
Posttranslational modification
Homeostasis
Oxidative stress
Subjects
Details
- ISSN :
- 20090897
- Database :
- OpenAIRE
- Journal :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Accession number :
- edsair.doi.dedup.....2c28e7ce9c51eace6507074ac4e93242
- Full Text :
- https://doi.org/10.1016/b978-0-12-803951-9.00003-3