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Cholecystokinin loses its satiating property in food deprived rats
- Source :
- Physiology & Behavior. 56:1091-1094
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- Facial consummatory responses reflecting ingestive and aversive perceptions were studied and quantified in rats chronically implanted with oral catheters. A gustatory stimulus of 50 microliters of 1.75 mol.l-1 sucrose was injected into the mouth every 5 min during 65 min. Five minutes after the beginning of the session, 2 micrograms.kg-1 cholecystokinin (CCK) were injected IP Typical ingestive facial consummatory responses were observed in response to sweet stimuli before IP CCK. Aversive consummatory responses were observed in response to sweet stimuli after the IP CCK (negative alliesthesia). In the second part of the experiment the rats were denied access to food for 36 h and their mean body weight decreased from 426 g to 395 g. When the food deprived rats were subjected again to the same gustatory sessions, the IP CCK was not followed by negative alliesthesia in response to sweet stimuli. After recovery of initial body weights CCK was followed again by a strong negative alliesthesia. These results in rats show that the CCK mediation of duodenal satiety was hindered by body weight decrease.
- Subjects :
- Male
medicine.medical_specialty
Hunger
Body Weight
digestive, oral, and skin physiology
Experimental and Cognitive Psychology
Sweet taste
Alliesthesia
Body weight
Satiety Response
Rats
Rats, Sprague-Dawley
Food Preferences
Behavioral Neuroscience
Endocrinology
Feeding behavior
Taste
Internal medicine
Gustatory stimulus
medicine
Animals
Psychology
Injections, Intraperitoneal
hormones, hormone substitutes, and hormone antagonists
Cholecystokinin
Subjects
Details
- ISSN :
- 00319384
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Physiology & Behavior
- Accession number :
- edsair.doi.dedup.....2c27db5990a1502b6fc805261d16ff4c