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Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis
- Source :
- Clinical Neurophysiology. 127:864-869
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- OBJECTIVES: The aim of this study was to determine the extent of autonomic dysfunction in patients with clinically isolated syndrome (CIS) by using a standardized battery of autonomic tests in the form of the Composite Autonomic Scoring Scale (CASS). ----- METHODS: This was a prospective, cross sectional study which included 24 consecutive patients who were diagnosed with CIS and 17 healthy controls. In all participants, heart rate and blood pressure responses to the Valsalva maneuver, heart rate response to deep breathing and blood pressure response to passive tilt were performed. In 16 patients, Quantitative Sudomotor Axon Reflex Test (QSART) and catecholamine measurement was performed. ----- RESULTS: The proportion of CIS patients with pathological adrenergic index was statistically significantly higher compared to healthy controls (12 vs 2, p=0.018), while there was no difference in cardiovagal index between groups. Five patients had a sudomotor index of 1 (in 4 there was hypohydrosis
- Subjects :
- Adult
Male
medicine.medical_specialty
Sympathetic nervous system
Multiple Sclerosis
medicine.medical_treatment
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Internal medicine
Heart rate
medicine
Valsalva maneuver
Humans
Prospective Studies
Autonomic dysfunction
Clinically isolated syndrome
Composite Autonomic Scoring Scale
business.industry
Multiple sclerosis
medicine.disease
Sensory Systems
Sudomotor
Autonomic nervous system
Cross-Sectional Studies
Blood pressure
medicine.anatomical_structure
Endocrinology
Autonomic Nervous System Diseases
Neurology
Cardiology
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Demyelinating Diseases
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....2c2511969efd9474d4b543ca512408cf