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Functional image-guided stereotactic body radiation therapy planning for patients with hepatocellular carcinoma
- Source :
- Medical Dosimetry. 42:97-103
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The aim of the current planning study is to evaluate the ability of gadoxetate disodium-enhanced magnetic resonance imaging (EOB-MRI)–guided stereotactic body radiation therapy (SBRT) planning by using intensity-modulated radiation therapy (IMRT) techniques in sparing the functional liver tissues during SBRT for hepatocellular carcinoma. In this study, 20 patients with hepatocellular carcinoma were enrolled. Functional liver tissues were defined according to quantitative liver-spleen contrast ratios ≥ 1.5 on a hepatobiliary phase scan. Functional images were fused with the planning computed tomography (CT) images; the following 2 SBRT plans were designed using a “step-and-shoot” static IMRT technique for each patient: (1) an anatomical SBRT plan optimization based on the total liver; and (2) a functional SBRT plan based on the functional liver. The total prescribed dose was 48 gray (Gy) in 4 fractions. Dosimetric parameters, including dose to 95% of the planning target volume (PTV D 95% ), percentages of total and functional liver volumes, which received doses from 5 to 30 Gy (V5 to V30 and fV5 to fV30), and mean doses to total and functional liver (MLD and fMLD, respectively) of the 2 plans were compared. Compared with anatomical plans, functional image-guided SBRT plans reduced MLD (mean: plan A, 5.5 Gy; and plan F, 5.1 Gy; p p
- Subjects :
- Gadolinium DTPA
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
Stereotactic body radiation therapy
medicine.medical_treatment
Planning target volume
Contrast Media
Computed tomography
Radiosurgery
Functional image
Multimodal Imaging
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Image Interpretation, Computer-Assisted
Planning study
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Aged
Aged, 80 and over
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Radiotherapy Planning, Computer-Assisted
Liver Neoplasms
Reproducibility of Results
Radiotherapy Dosage
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Radiation therapy
Treatment Outcome
Oncology
Subtraction Technique
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Female
Radiology
Tomography, X-Ray Computed
business
Nuclear medicine
Radiotherapy, Image-Guided
Subjects
Details
- ISSN :
- 09583947
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Medical Dosimetry
- Accession number :
- edsair.doi.dedup.....2c1f83c723d11cdfcbc9ba90bc815e51