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Osmotic regulation of gene action
- Source :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1994, 91 (5), pp.1657-1661
- Publication Year :
- 1994
- Publisher :
- HAL CCSD, 1994.
-
Abstract
- Most reactions involved in gene translation systems are ionic-dependent and may be explained in electrostatic terms. However, a number of observations of equilibria and rate processes making up the overall reactions clearly indicate that there is still an enormous gap between the rough picture of the mechanism of ionic regulation and the detailed behavior of reactions at the molecular level that hold the key to specific mechanisms. The present paper deals with possible osmotic contributions arising from the gel state of gene systems that are complementary to, and interdependent of, electrostatic contributions. This treatment, although still oversimplified, explains many previous observations by relating them to a general osmotic mechanism and suggests experimental approaches to studying the mechanisms of gene regulation in organelle-free and intact systems.
- Subjects :
- Osmosis
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Models, Biological
03 medical and health sciences
Biopolymers
0302 clinical medicine
Molecular level
Cations
Escherichia coli
Gene
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Genetics
Regulation of gene expression
0303 health sciences
Multidisciplinary
Osmotic concentration
Mechanism (biology)
Gene Expression Regulation, Bacterial
Gene Expression Regulation
Action (philosophy)
Biophysics
Gel state
Gels
Ribosomes
030217 neurology & neurosurgery
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1994, 91 (5), pp.1657-1661
- Accession number :
- edsair.doi.dedup.....2c188a3daad6ea04cced0847a9b6963a