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The RooPfs study to assess whether improved housing provides additional protection against clinical malaria over current best practice in The Gambia: study protocol for a randomized controlled study and ancillary studies
- Source :
- Trials, Trials, 2016, Vol.17(1), pp.275 [Peer Reviewed Journal]
- Publication Year :
- 2016
- Publisher :
- BioMed Central, 2016.
-
Abstract
- Background In malaria-endemic areas, residents of modern houses have less malaria than those living in traditional houses. This study will determine if modern housing provides incremental protection against clinical malaria over the current best practice of long-lasting insecticidal nets (LLINs) and prompt treatment in The Gambia, determine the incremental cost-effectiveness of the interventions, and analyze the housing market in The Gambia. Methods/design A two-armed, household, cluster-randomized, controlled study will be conducted to assess whether improved housing and LLINs combine to provide better protection against clinical malaria in children than LLINs alone in The Gambia. The unit of randomization will be the household, defined as a house and its occupants. A total of 800 households will be enrolled and will receive LLINs, and 400 will receive improved housing before clinical follow-up. One child aged 6 months to 13 years will be enrolled from each household and followed for clinical malaria using active case detection to estimate malaria incidence for two malaria transmission seasons. Episodes of clinical malaria will be the primary endpoint. Study children will be surveyed at the end of each transmission season to estimate the prevalence of Plasmodium falciparum infection, parasite density, and the prevalence of anemia. Exposure to malaria parasites will be assessed using light traps, followed by detection of Anopheles gambiae species and sporozoite infection. Ancillary economic and social science studies will undertake a cost-effectiveness analysis and use qualitative and participatory methods to explore the acceptability of the housing modifications and to design strategies for scaling-up housing interventions. Discussion The study is the first of its kind to measure the efficacy of housing on reducing clinical malaria, assess the incremental cost-effectiveness of improved housing, and identify mechanisms for scaling up housing interventions. Trial findings will help inform policy makers on improved housing for malaria control in sub-Saharan Africa. Trial registration ISRCTN Registry, ISRCTN02622179. Registered on 23 September 2014. Electronic supplementary material The online version of this article (doi:10.1186/s13063-016-1400-7) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
Veterinary medicine
Mosquito Control
Time Factors
Cost effectiveness
Anopheles gambiae
Cost-Benefit Analysis
Psychological intervention
Medicine (miscellaneous)
law.invention
Study Protocol
0302 clinical medicine
Randomized controlled trial
law
Risk Factors
Clinical endpoint
Prevalence
Pharmacology (medical)
030212 general & internal medicine
Malaria, Falciparum
Child
biology
Insecticide-treated bed net
Incidence
Age Factors
Anemia
Health Care Costs
3. Good health
Long-lasting insecticidal nets
Research Design
Child, Preschool
Household randomized controlled trial
Female
Gambia
Seasons
Adolescent
Malaria control
Best practice
030231 tropical medicine
1102 Cardiovascular Medicine And Haematology
Unit (housing)
03 medical and health sciences
General & Internal Medicine
Environmental health
parasitic diseases
Clinical malaria
medicine
Humans
Insecticide-Treated Bednets
business.industry
Infant
1103 Clinical Sciences
medicine.disease
biology.organism_classification
House screening
Housing
Cost-effectiveness
business
Malaria
Subjects
Details
- Language :
- English
- ISSN :
- 17456215
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Trials
- Accession number :
- edsair.doi.dedup.....2c0f74606011dd1367e210c2f109c67a