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Chromosome aberrations induced by protons up to 31 MeV in cultured human cells
- Source :
- Radiation and Environmental Biophysics. 19:91-100
- Publication Year :
- 1981
- Publisher :
- Springer Science and Business Media LLC, 1981.
-
Abstract
- Chromosome aberrations were induced in cultured human cells by proton beams of 31, 12, and 8 MeV. The frequencies of isochromatid breaks and dicentrics have been analysed as a function of proton energy and dose. Both effects are largely dependent on proton energy; isochromatid breaks increased linearly with the dose, whereas dicentrics show a definite parabolic behaviour. The experimental data were fitted to the analytic form Y = KDn and Y = alpha D + beta D2 and the best fitted values of the parameters are reported and discussed. The values of RBE for the isochromatid breaks are in the ratio 1.7:1.3:1 for 8, 12, and 31 MeV respectively. In the case of the dicentrics the RBE values are dose-dependent function of the type CD-n. The three distributions of dicentrics among the cells do not fit a Poisson distribution.
- Subjects :
- Chromosome Aberrations
Radiation
Proton
business.industry
Biophysics
Chromosome
Dose-Response Relationship, Radiation
Biology
Human cell
Proton energy
Cell Line
Optics
Nuclear magnetic resonance
Energy Transfer
Humans
Protons
business
Relative Biological Effectiveness
General Environmental Science
Subjects
Details
- ISSN :
- 14322099 and 0301634X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Radiation and Environmental Biophysics
- Accession number :
- edsair.doi.dedup.....2c0691aa5f40dee44ea792970a0ce7e9