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Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
- Source :
- FEBS Letters. 579:6885-6889
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- We have earlier reported overexpression of the central and peripheral cannabinoid receptors CB1 and CB2 in mantle cell lymphoma (MCL), a B cell non-Hodgkin lymphoma. In this study, treatment with cannabinoid receptor ligands caused a decrease in viability of MCL cells, while control cells lacking CB1 were not affected. Interestingly, equipotent doses of the CB1 antagonist SR141716A and the CB1/CB2 agonist anandamide inflicted additive negative effects on viability. Moreover, treatment with the CB1/CB2 agonist Win-55,212-2 caused a decrease in long-term growth of MCL cells in culture. Induction of apoptosis, as measured by FACS/Annexin V–FITC, contributed to the growth suppressive effect of Win-55,212-2. Our data suggest that cannabinoid receptors may be considered as potential therapeutic targets in MCL.
- Subjects :
- Cannabinoid receptor
Biopsy
Apoptosis
Lymphoma, Mantle-Cell
Growth
Ligands
Biochemistry
Leukemia, Plasma Cell
Mice
Piperidines
immune system diseases
Structural Biology
hemic and lymphatic diseases
Cannabinoid receptor type 1
Cannabinoid receptor type 2
Receptors, Cannabinoid
Receptor
Cells, Cultured
Cell Line, Transformed
Cell Death
Chemistry
Cannabinoid Receptor Agonists
Flow Cytometry
Endocannabinoid system
medicine.anatomical_structure
Viability
Female
lipids (amino acids, peptides, and proteins)
Rimonabant
Cell Division
psychological phenomena and processes
Polyunsaturated Alkamides
Morpholines
Biophysics
Breast Neoplasms
Arachidonic Acids
Naphthalenes
Cell Line
Cell Line, Tumor
Genetics
medicine
Animals
Humans
Cannabinoid Receptor Antagonists
Molecular Biology
B cell
Mantle cell lymphoma
Dose-Response Relationship, Drug
Cannabinoids
Cell Biology
Cell Transformation, Viral
Benzoxazines
Immunology
Cancer research
Pyrazoles
Cannabinoid receptor antagonist
Endocannabinoids
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 579
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....2c0623acb5b1fd30073aba204604ee0e