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Decision-making factors for best supportive care alone and prognostic factors after best supportive care in non-small cell lung cancer patients
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Among patients with non-small cell lung cancer (NSCLC), best supportive care (BSC) is well-known to improve patient’s quality of life and prolong survival. This study aimed to clarify (1) the decision-making factors of BSC alone and (2) the prognostic factors after selection of no further anticancer therapies. We retrospectively reviewed the clinical data of patients with NSCLC between November 2004 and February 2014, who received BSC as only therapy and BSC after completion of anticancer therapies. One hundred eighteen patients received BSC alone. Among 860 patients treated with anticancer therapies, 236 were selected as control group, 160 of whom received BSC after anticancer therapy. The significant reasons for receiving BSC alone were: comorbidities of dementia, poor Eastern Cooperative Oncology Group performance status (ECOG-PS), patients’ wishes, pulmonary comorbidities, wild type epidermal growth factor receptor (EGFR), relevant social background and psychiatric comorbidities. Poor prognostic factors at the start of BSC were poor ECOG-PS, presence of disseminated intravascular coagulation (DIC), and history of anticancer therapy. NSCLC patients with comorbidities, wild type EGFR, and relevant social background factors tended to receive BSC alone. Post-cancer therapy NSCLC patients and those with DIC and declining ECOG-PS have a shorter survival period from the start of BSC.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Lung Neoplasms
viruses
MEDLINE
lcsh:Medicine
Article
03 medical and health sciences
0302 clinical medicine
Quality of life
Carcinoma, Non-Small-Cell Lung
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Carcinoma
Humans
Dementia
030212 general & internal medicine
lcsh:Science
Lung cancer
Proportional Hazards Models
Retrospective Studies
Disseminated intravascular coagulation
Multidisciplinary
urogenital system
Proportional hazards model
business.industry
lcsh:R
Retrospective cohort study
biochemical phenomena, metabolism, and nutrition
Prognosis
medicine.disease
ErbB Receptors
Logistic Models
030220 oncology & carcinogenesis
Quality of Life
Palliative care
lcsh:Q
business
Non-small-cell lung cancer
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....2c010e35269a42e440c7ffd82c0a3e02
- Full Text :
- https://doi.org/10.1038/s41598-019-56431-w