The linoleic acid metabolite 13-HODE modulates degranulation of human polymorphonuclear leukocytes

The effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid (13-HODE) on degranulation of human polymorphonuclear leukocytes (PMNs) was investigated by measuring the expression of CD11b and CD67 on the plasma membrane. 13-HODE (5 μM) by itself induced degranulation of PMNs, but to a lesser extent as compared to PAF and fMLP. In addition, 13-HODE was found to inhibit the PAF-induced degranulation whereas an additive effect on the fMLP-induced PMNs degranulation was observed. These results indicate that 13-HODE can play a modulatory role in degranulation of PMNs.