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Polymorphisms in the interleukin-10 gene and relation to phenotype in patients with ulcerative colitis
- Source :
- Revista Española de Enfermedades Digestivas v.98 n.2 2006, SciELO España. Revistas Científicas Españolas de Ciencias de la Salud, instname, Europe PubMed Central
- Publication Year :
- 2006
-
Abstract
- BACKGROUND AND OBJECTIVES Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation in inflammatory bowel disease. In our population of Spanish ulcerative colitis (UC) patients, we have previously demonstrated that two polymorphisms (IL-10.G14 microsatellite allele and homozygous for the -1082G allele (guanine at position -1082)) in the IL-10 gene were susceptibility markers for disease. No data exist regarding the relationship of these IL-10 polymorphisms with phenotypic subpopulations in UC. Therefore, this study sought to examine the contribution of IL-10 polymorphisms to phenotypical variability in UC. MATERIAL AND METHODS A cohort of 215 Spanish unrelated patients with UC recruited in a single center was studied. All patients were rigorously phenotyped and followed for at least 3 years (mean time: 11.8 years). The clinical phenotype was established before genotyping. Genotyping was performed using polymerase chain reaction (PCR) assays. RESULTS Patients with UC included 129 (60%) men and 89 (40%) women. Mean age at diagnosis was 38 years, with a range of 8-83. Disease extent included 127 (59.1%) left-side patients and 88 (40.9%) extensive patients. Neither UC phenotype variable was associated with the presence of susceptibility polymorphisms (10G14 microsatellite and -1082G allele). CONCLUSIONS In Madrid's Spanish population of UC patients, the carrying of the ILG14 microsatellite or -1082G polymorphism in the IL-10 gene was not associated with phenotype of disease.
- Subjects :
- Adult
Male
Interleukin-10 gene
Adolescent
Genotype
Population
Inflammatory bowel disease
Polymorphism (computer science)
Medicine
Humans
Allele
education
Child
Genotyping
Aged
Aged, 80 and over
education.field_of_study
Polymorphism, Genetic
business.industry
Gastroenterology
General Medicine
Middle Aged
medicine.disease
Ulcerative colitis
Interleukin-10
Phenotype
Spain
Immunology
Microsatellite
Colitis, Ulcerative
Female
business
Subjects
Details
- ISSN :
- 11300108
- Volume :
- 98
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva
- Accession number :
- edsair.doi.dedup.....2bdbecd829b735c8ee53cfda22610751