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Intracoronary Stem Cell Infusion in Heart Transplant Candidates
- Source :
- The Tohoku Journal of Experimental Medicine. 213:113-120
- Publication Year :
- 2007
- Publisher :
- Tohoku University Medical Press, 2007.
-
Abstract
- The stem cell transplantation is emerging as a potential therapeutic modality for patients with heart failure. It has been demonstrated that intracoronary stem cell transplantation had beneficial effects on left ventricular perfusion and contractile functions. We hypothesized that patients with end-stage ischemic cardiomyopathy, who are candidates for heart transplantation, could also benefit from autologous intracoronary stem cell transplantation. We performed a prospective, open-labeled study in 10 patients with end-stage ischemic cardiomyopathy, who were on the waiting list for heart transplantation. Each patient received bone marrow-derived mononuclear cell infusion via balloon catheter in the target vessel, which had been revascularized by percutaneous intervention and was patent before the procedure. Clinical and laboratory evaluations, a treadmill exercise test, echocardiography, and single photon emission tomography (SPECT) were performed to the patients at baseline and 6 months after stem cell infusion. At 6-month follow-up of the eight patients who were able to complete the study, we revealed a significant increase in ejection fraction (from 30.0 +/- 6.6% to 36.2 +/- 7.3%; p = 0.001) in echocardiographic evaluation. SPECT evaluation also displayed a reduction in infarct area (50.4 +/- 16.1% to 44.1 +/- 12.5%; p = 0.003). Both myocardial oxygen consumption (p = 0.001) and metabolic equivalents (p = 0.001) were significantly increased at 6-month follow-up. These results demonstrate that intracoronary stem cell transplantation ameliorates heart failure symptoms and improves left ventricular function and perfusion. Therefore intracoronary stem cell transplantation may be used as an alternative treatment option for heart transplant candidates.
- Subjects :
- Male
Cardiac Catheterization
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Myocardial Ischemia
Coronary Angiography
Severity of Illness Index
Transplantation, Autologous
Ventricular Function, Left
General Biochemistry, Genetics and Molecular Biology
Electrocardiography
Oxygen Consumption
Coronary Circulation
Internal medicine
Cellular cardiomyoplasty
medicine
Humans
Infusions, Intra-Arterial
Prospective Studies
Bone Marrow Transplantation
Tomography, Emission-Computed, Single-Photon
Heart transplantation
Ischemic cardiomyopathy
Ejection fraction
business.industry
Balloon catheter
Stroke Volume
General Medicine
Middle Aged
medicine.disease
Coronary Vessels
Transplantation
Treatment Outcome
Heart failure
Cardiology
Feasibility Studies
Heart Transplantation
Female
Stem cell
business
Follow-Up Studies
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 13493329 and 00408727
- Volume :
- 213
- Database :
- OpenAIRE
- Journal :
- The Tohoku Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....2bccd19500d7cf6190a3868fae2449f6