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Transformation of canine lymphoma/leukemia to more aggressive diseases: Anecdotes or reality?
- Source :
- Frontiers in Veterinary Science, Frontiers in Veterinary Science, Vol 2 (2015)
- Publication Year :
- 2015
-
Abstract
- Transformation is the evolution of an indolent lymphoma/leukemia to an aggressive lymphoma, typically harboring a very poor prognosis. This phenomenon is well described in humans , but under-estimated in dogs although recognized as a possible evolution of indolent lymphomas/leukemias. In canine chronic leukemias blast crisis (mainly in myeloid ) and Richter syndrome (transformation into a high grade lymphoma) (mainly in B-cell lymphocytic leukemia) has been reported. Transformation is a possible event also in canine low grade lymphomas, although rare. The increased knowledge has also generated new questions and posed challenges that need to be addressed to improve outcome, including the recognition of the clinical characteristics at diagnosis associated with a higher risk of transformation in an attempt of anticipating the typical evolution.
- Subjects :
- Oncology
medicine.medical_specialty
Richter syndrome
Pathology
Poor prognosis
Blast Crisis
Myeloid
Lymphoma
Aggressive lymphoma
Transformation
Internal medicine
hemic and lymphatic diseases
medicine
Dog
Indolent
DLBC
Canine Lymphoma
lcsh:Veterinary medicine
Leukemia
General Veterinary
business.industry
DLBCL
blast crisis
dog
indolent
leukemia
lymphoma
transformation
medicine.disease
Blast crisi
medicine.anatomical_structure
Perspective
lcsh:SF600-1100
Veterinary Science
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Frontiers in Veterinary Science, Frontiers in Veterinary Science, Vol 2 (2015)
- Accession number :
- edsair.doi.dedup.....2bc0d410e380d0d64e8d64648974049e