Back to Search
Start Over
Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice
- Source :
- European Journal of Immunology, Vol. 34, No 12 (2004) pp. 3713-3722
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- C1q deficiency in both humans and mice is strongly associated with autoimmunity. We have previously shown that bone marrow transplantation (BMT) restored C1q levels in C1q-deficient (C1qa(-/-)) mice. Here, we studied the effect of BMT on autoimmunity in C1qa(-/-) mice. Following irradiation, young C1qa(-/-) or wild-type MRL/Mp mice received bone marrow cells (BMC) from strain-matched wild-type or C1qa(-/-) animals. C1q levels increased rapidly when C1qa(-/-) mice received BMC from wild-type mice. Conversely, they decreased slowly in wild-type mice transplanted with C1qa(-/-) BMC. C1qa(-/-) animals transplanted with C1qa(-/-) BMC demonstrated accelerated disease when compared with wild-type mice given wild-type BMC. In contrast, a significant delay in the development of autoantibodies and glomerulonephritis was observed in C1qa(-/-) mice reconstituted with wild-type BMC, and the impaired clearance of apoptotic cells, previously described in C1qa(-/-) mice, was rectified. Moreover, the autoimmune disease was accelerated in wild-type mice given C1qa(-/-) BMC compared to animals transplanted with wild-type cells. These results provide supporting evidence that BMT may be a therapeutic option in the treatment of autoimmunity associated with human C1q deficiency.
- Subjects :
- Phagocytosis/immunology/physiology
medicine.medical_specialty
Rodent
Immunology
Complement C1q/deficiency/immunology/*metabolism
ddc:616.07
Spleen/metabolism
medicine.disease_cause
Autoimmune Diseases
Autoimmunity
Mice
Phagocytosis
Autoimmune Diseases/immunology/*therapy
immune system diseases
Internal medicine
biology.animal
medicine
Animals
Immunology and Allergy
Bone Marrow Transplantation
Autoimmune disease
biology
business.industry
Complement C1q
Autoantibody
Glomerulonephritis
medicine.disease
Transplantation
medicine.anatomical_structure
Endocrinology
Apoptosis
Bone marrow
business
Spleen
Subjects
Details
- ISSN :
- 15214141 and 00142980
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi.dedup.....2bbceaebe2ecfd1e30fb9e6af7de4419