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Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: a split-mouth randomized controlled trial
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2014
-
Abstract
- The management of aggressive periodontitis (AgP) represents a challenge for clinicians because there are no standardized protocols for an efficient control of the disease. This randomized controlled clinical trial evaluated the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) adjunctive to scaling and root planing (SRP) in patients with AgP.Using a split-mouth design, 20 patients with generalized AgP were treated with aPDT + SRP (test group) or SRP only (control group). aPDT was applied at four periods. All patients were monitored for 90 days. Clinical, microbiologic, and immunologic parameters were statistically analyzed.In deep periodontal pocket analysis (probing depth [PD] ≥ 7 mm at baseline), the test group presented a decrease in PD and a clinical attachment gain significantly higher than the control group at 90 days (P0.05). The test group also demonstrated significantly less periodontal pathogens of red and orange complexes and a lower interleukin-1β/interleukin-10 ratio than the control group (P0.05).The application of four sessions of aPDT, adjunctive to SRP, promotes additional clinical, microbiologic, and immunologic benefits in the treatment of deep periodontal pockets in single-rooted teeth in patients with AgP.
- Subjects :
- Adult
Male
medicine.medical_specialty
Gingival and periodontal pocket
Adolescent
medicine.medical_treatment
Interleukin-1beta
Dental Plaque
Dentistry
Photodynamic therapy
Gastroenterology
law.invention
Root Planing
Young Adult
Scaling and root planing
Randomized controlled trial
Double-Blind Method
law
Phenothiazines
Internal medicine
Periodontal Attachment Loss
Medicine
Aggressive periodontitis
Humans
Periodontal Pocket
PERIODONTITE AGRESSIVA
Gram-Negative Anaerobic Bacteria
Photosensitizing Agents
business.industry
Non surgical treatment
Gingival Crevicular Fluid
Antimicrobial
medicine.disease
Combined Modality Therapy
Bacterial Load
Interleukin-10
Clinical trial
Aggressive Periodontitis
Photochemotherapy
Periodontics
Dental Scaling
Female
Lasers, Semiconductor
business
Subjects
Details
- ISSN :
- 19433670
- Volume :
- 86
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of periodontology
- Accession number :
- edsair.doi.dedup.....2badf06731a581f2f01932ced4c195a5