Back to Search
Start Over
Phenoxymethylpenicillin and Therapeutic Failure in Acute Otitis Media
- Source :
- Archives Of Physiology And Biochemistry. 17:367-370
- Publication Year :
- 1985
- Publisher :
- Informa UK Limited, 1985.
-
Abstract
- The aim of the present investigation was to determine to what extent beta-lactamase producing Haemophilus influenzae (H.i.) and Branhamella catarrhalis (B.c.) were isolated in cases of failure of treatment of acute otitis media (AOM) with phenoxymethylpenicillin. Among children with suspected therapeutic failure referred to an ENT specialist altogether 11, 15% of those referred, fulfilled the criteria of AOM. Three of them were on erythromycin, 1 on ampicillin and 7 on phenoxymethylpenicillin. In 5 of the children treated with phenoxymethylpenicillin H.i. was isolated from middle ear exudate and/or the nasopharynx. All H.i. isolates were non-capsulated and beta-lactamase negative. One beta-lactamase producing B.c. was isolated from the nasopharynx in a patient with pure culture of H.i. in the ear exudate. The present investigation did not support the suggestion that beta-lactamase producing H.i. or B.c. are major causative agents in therapeutic failures of AOM treated with phenoxymethylpenicillin and did not produce any evidence supporting a change from the recommended ampicillin esters/amoxycillin in therapeutic failures.
- Subjects :
- medicine.medical_specialty
Physiology
Acute otitis media
Erythromycin
medicine.disease_cause
beta-Lactamases
Haemophilus influenzae
Recurrence
Nasopharynx
Physiology (medical)
Internal medicine
Ampicillin
otorhinolaryngologic diseases
medicine
Humans
Branhamella catarrhalis
business.industry
General Medicine
Otitis Media
Phenoxymethylpenicillin
medicine.anatomical_structure
Acute Disease
Middle ear
Penicillin V
Therapeutic failure
business
Neisseria
medicine.drug
Subjects
Details
- ISSN :
- 13813455
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Archives Of Physiology And Biochemistry
- Accession number :
- edsair.doi.dedup.....2ba212d6dafdd38bc2f82e5b46554dc0