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The discovery of new spirocyclic muscarinic M3 antagonists
- Source :
- Bioorganic & Medicinal Chemistry Letters. 20:7458-7461
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The optimisation of a new series of high potency muscarinic M3 antagonists, derived from high throughput screening library hit is described.
- Subjects :
- Receptor, Muscarinic M3
Chemistry
High-throughput screening
Organic Chemistry
Clinical Biochemistry
Drug Evaluation, Preclinical
Antagonist
Pharmaceutical Science
Muscarinic acetylcholine receptor M3
Biochemistry
Chemical synthesis
Rats
Microsomes
Drug Discovery
Muscarinic acetylcholine receptor
Hepatocytes
Animals
Humans
Molecular Medicine
Potency
Spiro Compounds
Molecular Biology
Acetylcholine receptor
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....2b9303d8fd2483e822cacf764e13f739
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.10.016