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Role of oxidative stress in the pathophysiology of bipolar disorder
- Source :
- Neurochemical Research. 35:1295-1301
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- In this work, we review the studies of oxidative stress markers, showing association with the pathophysiology of bipolar disorder (BD). BD is a prevalent, chronic and highly disabling psychiatric disorder. Several hypotheses have been postulated to explain the exact neurochemical mechanisms underlying the pathophysiology of BD, including a role for monoamines, gamma-amino butyric acid (GABA), glutamate, and second messenger singling pathways. More recently, oxidative stress has been implicated in the pathogenesis of BD. Recent studies have reported increased products of lipid peroxidation and alterations of the major antioxidants enzymes in patients with BD. It has been widely demonstrated that the generation of reactive oxygen species (ROS) plays a critical role in the pathophysiology of several neuropsychiatric disorders, such BD.
- Subjects :
- Bipolar Disorder
DNA damage
medicine.disease_cause
Biochemistry
Antioxidants
Lipid peroxidation
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Neurochemical
medicine
Animals
Humans
Bipolar disorder
chemistry.chemical_classification
Reactive oxygen species
Chemistry
Glutamate receptor
General Medicine
medicine.disease
Pathophysiology
Mitochondria
Oxidative Stress
Immunology
Lipid Peroxidation
Reactive Oxygen Species
Biomarkers
Oxidative stress
DNA Damage
Subjects
Details
- ISSN :
- 15736903 and 03643190
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Neurochemical Research
- Accession number :
- edsair.doi.dedup.....2b8ea0fe84d59d61d463222fa0bb7ce8