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Preliminary clinical assessment and non- toxicity evaluation of an ayurvedic formulation BGR-34 in NIDDM
- Source :
- Journal of Traditional and Complementary Medicine, Journal of Traditional and Complementary Medicine, Vol 8, Iss 4, Pp 506-514 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- In view of the overall health impact of NIDDM, inventers understand the necessity of improving glycemic control in adults with type 2 diabetes. BGR-34 provides an effective treatment option for adults with type 2 diabetes who have been inadequately controlled on lifestyle with or without other oral hypoglycemic agents (OHGAs) such as metformin, sulfonylurea, or a glitazones. BGR-34 is an appropriate option to consider for addition to a managed care drug formulary. Treatment with BGR-34 produced clinically relevant and statistically significant reductions in all three key measures of glucose control studied —FPG, PPBG and HbA1c— when compared with placebo. BGR-34, showed the promising result with respect to glycemic parameters in NIDDM patient with a significant reduction in fasting blood sugar by 34.3%, postprandial blood sugar 35.5% & glycosylated haemoglobin by 20.31% as compared to placebo group showing a reduction by 13.2%, 10.9% & 10.87% respectively. The trial has also been registered to CTRI, India. This study has been registered in the clinical trial registry-India.<br />Graphical abstract BGR 34, has been investigated to contain a number of active biomolecule molecules including the compound ‘berberine’ (source; Berberis aristata), a natural dipeptidyl peptidase IV (DPP-4) inhibitor, that act by increasing endogenous GLP-1 and GIP concentrations.Image 1
- Subjects :
- OPD, out Patient Department
medicine.medical_specialty
Indian system medicine
medicine.drug_class
CTRI, clinical trial registry-India
lcsh:Medicine
Blood sugar
Type 2 diabetes
Placebo
NIDDM, noninsulin-dependent diabetes mellitus
TLC, TOTAL leukocyte count
BGR-34
03 medical and health sciences
HbA1c, glycosylated haemoglobin
0302 clinical medicine
NIDDM
Internal medicine
Medicine
CPCSEA, committee for the purpose of conduct and supervisions of experiments on rats
DLC, differential leukocyte count
030212 general & internal medicine
FPG, fasting plasma glucose
Berberis aristata
Glycemic
BBN, total bilirubin
ALP, alkaline phosphatase
HDL, high-density lipoproteins
business.industry
lcsh:R
medicine.disease
SGPT, serum glutamate pyruvate transaminase
Sulfonylurea
Metformin
SGOT, serum glutamate oxaloacetate transaminase
Clinical trial
Postprandial
Complementary and alternative medicine
OHGAs, other oral hypoglycemic agents
Hb, haemoglobin
030220 oncology & carcinogenesis
PPBG, post-prandial blood glucose
Original Article
OECD, organization for economic co-operation and development
business
CSIR, council of scientific & industrial research, india
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 22254110
- Volume :
- 8
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Traditional and Complementary Medicine
- Accession number :
- edsair.doi.dedup.....2b8892b01676c68fce2f1b9259443dbd