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Aspergillus fumigatus in cystic fibrosis: An update on immune interactions and molecular diagnostics in allergic bronchopulmonary aspergillosis
- Source :
- Allergy, Allergy, 2017, 72 (11), pp.1632-1642. ⟨10.1111/all.13204⟩, Allergy, Wiley, 2017, 72 (11), pp.1632-1642. ⟨10.1111/all.13204⟩
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- International audience; A wide spectrum of pathological conditions may result from the interaction of Aspergillus fumigatus and the immune system of its human host. Allergic bronchopulmonary aspergillosis is one of the most severe A.fumigatus-related diseases due to possible evolution toward pleuropulmonary fibrosis and respiratory failure. Allergic bronchopulmonary aspergillosis occurs almost exclusively in cystic fibrosis or asthmatic patients. An estimated 8%-10% of patients with cystic fibrosis experience this condition. The diagnosis of allergic bronchopulmonary aspergillosis relies on criteria first established in 1977. Progress in the understanding of host-pathogen interactions in A.fumigatus and patients with cystic fibrosis and the ongoing validation of novel laboratory tools concur to update and improve the diagnosis of allergic bronchopulmonary aspergillosis.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Cystic Fibrosis
Immunology
Cystic fibrosis
Aspergillus fumigatus
03 medical and health sciences
0302 clinical medicine
Immune system
Fibrosis
medicine
Humans
Immunology and Allergy
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
biology
business.industry
Aspergillosis, Allergic Bronchopulmonary
biology.organism_classification
medicine.disease
Molecular diagnostics
3. Good health
030104 developmental biology
030228 respiratory system
Respiratory failure
Host-Pathogen Interactions
biology.protein
Antibody
Allergic bronchopulmonary aspergillosis
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- ISSN :
- 13989995 and 01054538
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Allergy
- Accession number :
- edsair.doi.dedup.....2b85712b7def9aad4d0d6a7245f6d49a