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Synthesis and Antiproliferative Activity of [RuCp(PPh3)2(HdmoPTA)](OSO2CF3)2 (HdmoPTA = 3,7-H-3,7-Dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)
- Source :
- Inorganic chemistry 55 (2016): 7820–7822. doi:10.1021/acs.inorgchem.6b01207, info:cnr-pdr/source/autori:Mendoza Z.; Lorenzo-Luis P.; Serrano-Ruiz M.; Martin-Batista E.; Padron J.M.; Scalambra F.; Romerosa A./titolo:Synthesis and Antiproliferative Activity of [RuCp(PPh3)2(HdmoPTA)](OSO2CF3)2 (HdmoPTA = 3,7-H-3,7-Dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)/doi:10.1021%2Facs.inorgchem.6b01207/rivista:Inorganic chemistry/anno:2016/pagina_da:7820/pagina_a:7822/intervallo_pagine:7820–7822/volume:55
- Publication Year :
- 2016
-
Abstract
- The complex [RuCp(PPh3)2(HdmoPTA)](OSO2CF3)2 (2; HdmoPTA = 3,7-H-3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) was synthesized and characterized. Its crystal structure was determined by single-crystal X-ray diffraction. The complex showed a more potent antiproliferative activity than cisplatin against a representative panel of human cancer cells.
- Subjects :
- Stereochemistry
chemistry.chemical_element
Antineoplastic Agents
Crystal structure
Chemistry Techniques, Synthetic
010402 general chemistry
01 natural sciences
Ruthenium
transition metal complexes
Inorganic Chemistry
chemistry.chemical_compound
medicinal chemistry
Cell Line, Tumor
Alkanes
medicine
Molecule
Humans
Physical and Theoretical Chemistry
Solubility
Cell Proliferation
Cisplatin
Molecular Structure
010405 organic chemistry
0104 chemical sciences
chemistry
water soluble ligands
Nonane
Drug Screening Assays, Antitumor
Human cancer
medicine.drug
Subjects
Details
- ISSN :
- 1520510X
- Volume :
- 55
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Inorganic chemistry
- Accession number :
- edsair.doi.dedup.....2b809c52660cb841b156a7831b40b26e
- Full Text :
- https://doi.org/10.1021/acs.inorgchem.6b01207