Back to Search
Start Over
Enzymatic racemization of amines catalyzed by enantiocomplementary ω-transaminases
- Source :
- Chemistry (Weinheim an der Bergstrasse, Germany). 17(1)
- Publication Year :
- 2010
-
Abstract
- A strategy for the biocatalytic racemization of primary α-chiral amines was developed by employing a pair of stereocomplementary PLP-dependent ω-transaminases. The interconversion of amine enantiomers proceeded through reversible transamination by a prochiral ketone intermediate, either catalyzed by a pair of stereocomplementary ω-transaminases or by a single enzyme possessing low stereoselectivity. To tune the system, the type and concentration of a nonchiral amino acceptor proved to be crucial. Finally, racemization could be achieved by the cross-transamination of two different amines without a requirement for an external amino acceptor. Several synthetically and industrially important amines could be enzymatically racemized under mild reaction conditions.
- Subjects :
- chemistry.chemical_classification
Ketone
Molecular Structure
Transamination
Chromobacterium
Organic Chemistry
Stereoisomerism
General Chemistry
Ketones
Catalysis
chemistry
Biocatalysis
Bacillus megaterium
Escherichia coli
Organic chemistry
Amine gas treating
Stereoselectivity
Enantiomer
Amines
Racemization
Transaminases
Vibrio
Subjects
Details
- ISSN :
- 15213765
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Accession number :
- edsair.doi.dedup.....2b7cbab4051b546d5bd5986a5608a31e