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Effectiveness and Safety of Intensive Triplet Chemotherapy Plus Bevacizumab, FIr-B/FOx, in Young-Elderly Metastatic Colorectal Cancer Patients
- Source :
- BioMed Research International, BioMed Research International, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Publishing Corporation, 2013.
-
Abstract
- Four-drug regimens, such as FIr-B/FOx schedule, can improve efficacy of first-line treatment of metastatic colorectal cancer (MCRC) patients. The present study specifically evaluates feasibility of FIr-B/FOx first-line intensive regimen in fit young-elderly MCRC patients, representing approximately 40% of overall MCRC patients. Activity, efficacy, and safety were equivalent to overall MCRC patients, not significantly different according toKRASgenotype. Clinical outcome was significantly prolonged in liver-limited compared to other/multiple metastatic disease. Safety evaluation of the individual young-elderly patient showed that limiting toxicity syndromes (LTS) in multiple sites were significantly increased, compared to LTS in single site, with respect to non-elderly patients.
- Subjects :
- Oncology
Male
Organoplatinum Compounds
Colorectal cancer
DNA Mutational Analysis
Leucovorin
lcsh:Medicine
Disease
Kaplan-Meier Estimate
medicine.disease_cause
Carboplatin
chemistry.chemical_compound
Antineoplastic Combined Chemotherapy Protocols
Neoplasm Metastasis
General Medicine
Bevacizumab
Treatment Outcome
Fluorouracil
Female
KRAS
Colorectal Neoplasms
medicine.drug
medicine.medical_specialty
Genotype
Article Subject
Antibodies, Monoclonal, Humanized
General Biochemistry, Genetics and Molecular Biology
Proto-Oncogene Proteins p21(ras)
Clinical Trials, Phase II as Topic
Internal medicine
Proto-Oncogene Proteins
medicine
Humans
Aged
Demography
General Immunology and Microbiology
Dose-Response Relationship, Drug
business.industry
lcsh:R
medicine.disease
digestive system diseases
Surgery
Regimen
Methotrexate
chemistry
ras Proteins
Clinical Study
Camptothecin
business
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....2b793973c9f0a54f04ea6dacf2644c85
- Full Text :
- https://doi.org/10.1155/2013/143273