Sodiumodylate in Syphilis

I have been using sodium cacodylate in three cases of secondary and one case of tertiary syphilis. Each dose contained 3 grains of the drug. The cases are as follows: CASE 1. —A. M., male, aged 31, married, had been under mercurials and tonics for eight months. The only lesions present were two small mucous patches on the side of the tongue. Mercury was discontinued. On April 26, April 30 and May 10 the patient received 3-grain doses of sodium cacodylate. May 12 the patient was attacked by very severe cephalalgia, requiring opiate by hypodermic method to relieve. Mercury by inunction soon controlled the trouble. CASE 2. —Mrs. A., aged 28, had just recovered from secondary skin lesion under mercury. On April 26 and April 30 she received hypodermic injections, each containing 3 grains of the drug, into pectoral muscle. May 15 brown patches appeared on the arms and chest.