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Protective Angiotensin Type 2 Receptors in the Brain and Hypertension
- Source :
- de Kloet, A D, Steckelings, U M & Sumners, C 2017, ' Protective Angiotensin Type 2 Receptors in the Brain and Hypertension ', Current Hypertension Reports, vol. 19, 46 . https://doi.org/10.1007/s11906-017-0746-x
- Publication Year :
- 2017
-
Abstract
- PURPOSE OF REVIEW: The goal of this review is to assess the evidence that activation of angiotensin type 2 receptors (AT2R) in the brain can lower blood pressure and possibly constitute an endogenous anti-hypertensive mechanism.RECENT FINDINGS: Recent studies that detail the location of AT2R in the brain, particularly within or near cardiovascular control centers, mesh well with findings from pharmacological and gene transfer studies which demonstrate that activation of central AT2R can influence cardiovascular regulation. Collectively, these studies indicate that selective activation of brain AT2R causes moderate decreases in blood pressure in normal animals and more profound anti-hypertensive effects, along with restoration of baroreflex function, in rodent models of neurogenic hypertension. These findings have opened the door to studies that can (i) assess the role of specific AT2R neuron populations in depressing blood pressure, (ii) determine the relevance of such mechanisms, and (iii) investigate interactions between AT2R and depressor angiotensin-(1-7)/Mas mechanisms in the brain.
- Subjects :
- medicine.medical_specialty
Angiotensin receptor
Blood Pressure
Review
030204 cardiovascular system & hematology
Baroreflex
Compound 21
Solitary tract nucleus
Receptor, Angiotensin, Type 2
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Paraventricular nucleus
Renin–angiotensin system
Journal Article
Internal Medicine
Medicine
Animals
Humans
Antihypertensive Agents
Angiotensin II receptor type 1
business.industry
Brain
Neurogenic hypertension
medicine.disease
Endocrinology
Blood pressure
Pathophysiology of hypertension
Angiotensin type 2 receptor
Hypertension
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15343111
- Volume :
- 19
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Current hypertension reports
- Accession number :
- edsair.doi.dedup.....2b66470a552c8cace8a86ad8c896fc50