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Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway
- Source :
- Cell Biochemistry and Function
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most frequent cause of cancer-related death. The IRX5 transcription factor plays a different role in multiple cancers and contributes to the development of many tumours. However, little is known about the molecular mechanisms of IRX5 in HCC. In this study, we found that IRX5 was abnormally upregulated in HCC tissues compared with adjacent normal tissues. IRX5 promoted HCC cell proliferation and upregulated the expression of cyclin D1 and knockdown of IRX5 suppressed tumorigenicity in vivo. Furthermore, knockdown of IRX5 increased p53 and Bax expression and decreased Bcl-2 expression. Thus, IRX5 suppressed apoptosis in HCC cells by inhibiting the p53 signalling pathway, indicating its role as a treatment target for HCC. SIGNIFICANCE OF THE STUDY: Our study demonstrated that IRX5 was abnormally upregulated in HCC tissues compared with adjacent normal tissues. IRX5 promoted HCC cell proliferation and upregulated the expression of cyclin D1, and knockdown of IRX5 suppressed tumorigenicity in vivo. Furthermore, knockdown of IRX5 increased p53 and Bax expression and decreased Bcl-2 expression. IRX5 suppressed apoptosis in HCC cells by inhibiting the p53 signalling pathway, indicating its role as a treatment target for HCC.
- Subjects :
- Male
0301 basic medicine
Carcinoma, Hepatocellular
proliferation
Clinical Biochemistry
Mice, Nude
Biology
Biochemistry
Cell Line
Mice
03 medical and health sciences
Liver Neoplasms, Experimental
0302 clinical medicine
Cyclin D1
Downregulation and upregulation
medicine
Animals
Humans
p53 signalling pathway
neoplasms
Transcription factor
Research Articles
Cell Proliferation
Homeodomain Proteins
Mice, Inbred BALB C
Gene knockdown
Cell growth
Liver Neoplasms
apoptosis
hepatocellular carcinoma
Cell Biology
General Medicine
medicine.disease
digestive system diseases
Hedgehog signaling pathway
030104 developmental biology
Apoptosis
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Cancer research
IRX5
Tumor Suppressor Protein p53
Research Article
Signal Transduction
Transcription Factors
Subjects
Details
- ISSN :
- 10990844 and 02636484
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Cell Biochemistry and Function
- Accession number :
- edsair.doi.dedup.....2b582fac6e4c4254af8e33800f448555