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Ligusticum chuanxiong Prevents Ovariectomy-Induced Liver and Vascular Damage in Rats
- Source :
- The American Journal of Chinese Medicine. 41:831-848
- Publication Year :
- 2013
- Publisher :
- World Scientific Pub Co Pte Lt, 2013.
-
Abstract
- Post-menopause, there is an increase in body weight, visceral adiposity, and risk of developing non-alcoholic fatty liver disease (NAFLD), which leads to various cardiovascular diseases (CVDs). Some natural products have proven useful for counteracting the detrimental effects of menopause. The rhizome of Ligusticum chuanxiong Hort. (LC) is a well-known medicinal herb widely used in Chinese communities for the treatment of CVDs. The hepatic and vascular protective effects of LC ethanolic extract under postmenopausal conditions were investigated on ovariectomized (OVX) rats supplemented with or without LC ethanolic extract (600 mg/kg body weight/day, p.o.) or 17β-estradiol (1 mg/kg body weight/day, p.o.) for 12 weeks. The current findings demonstrated that consumption of LC ethanolic extract could reduce the body weight gain, improve serum lipid profile (lowering low density lipoprotein cholesterol but raising high density lipoprotein cholesterol), combat NAFLD, and protect vascular endothelium in the OVX rats. The beneficial effects of LC may be associated with its antioxidant or vasorelaxant compounds, which enhance the levels of hepatic antioxidant enzymes and up-regulate endothelial nitric oxide synthase mRNA expression, respectively. Taken together, LC may be a promising natural supplement for postmenopausal women to prevent NAFLD and CVDs.
- Subjects :
- medicine.medical_specialty
Antioxidant
Nitric Oxide Synthase Type III
Endothelium
Ovariectomy
medicine.medical_treatment
Aorta, Thoracic
Nitric Oxide
Weight Gain
Antioxidants
Nitric oxide
Rats, Sprague-Dawley
chemistry.chemical_compound
High-density lipoprotein
Non-alcoholic Fatty Liver Disease
Internal medicine
medicine
Animals
Ligusticum
Estradiol
medicine.diagnostic_test
Plant Extracts
Cholesterol
business.industry
Fatty liver
Estrogens
General Medicine
medicine.disease
Lipids
Rats
Fatty Liver
Postmenopause
Vasodilation
medicine.anatomical_structure
Endocrinology
Liver
Complementary and alternative medicine
chemistry
Ovariectomized rat
Female
Endothelium, Vascular
Lipid profile
business
Rhizome
Drugs, Chinese Herbal
Phytotherapy
Subjects
Details
- ISSN :
- 17936853 and 0192415X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- The American Journal of Chinese Medicine
- Accession number :
- edsair.doi.dedup.....2b507790075bbba463e624901c3ec4b6