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Adjuvant effect of antibodies against von Willebrand Factor, fibrinogen, and fibronectin on staphylokinase-induced thrombolysis as measured using mural thrombi formed in rat mesenteric venules
- Source :
- Thrombosis research. 97(5)
- Publication Year :
- 2000
-
Abstract
- The change in thrombus mass during thrombolytic therapy is thought to be the difference between its growth and its degradation induced by thrombolytic agents. Platelets play a pivotal role in arterial thrombosis and bind to each other and to exposed subendothelial matrices via adhesive proteins such as von Willebrand Factor, fibrinogen, and fibronectin. The aim of the present study was to assess whether administration of antibodies against these adhesive proteins, in conjunction with plasminogen activator, could enhance the degradation of platelet-rich thrombus. Mural platelet-rich thrombi were formed in rat mesenteric venules using He-Ne laser irradiation. Recombinant staphylokinase was infused continuously and polyclonal antibodies against adhesive proteins were given by bolus injection. The thrombolytic process was analysed using computer-enhanced image analysis software. Administration of each of the antibodies enhanced staphylokinase-induced thrombolysis.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Heart Diseases
Blood Pressure
Fibrinogen
Plasminogen Activators
Mesenteric Veins
Von Willebrand factor
Adjuvants, Immunologic
Fibrinolytic Agents
von Willebrand Factor
medicine
Animals
Platelet
Thrombolytic Therapy
Thrombus
Rats, Wistar
Venule
biology
business.industry
Immune Sera
Metalloendopeptidases
Staphylokinase
Thrombosis
Hematology
medicine.disease
Fibronectins
Rats
Immunoglobulin G
Immunology
biology.protein
business
Plasminogen activator
Fibrinolytic agent
medicine.drug
Subjects
Details
- ISSN :
- 00493848
- Volume :
- 97
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Thrombosis research
- Accession number :
- edsair.doi.dedup.....2b49bb7bb9e31a5cc4361d4f09643114