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Risk of hepatocellular carcinoma development in cases of hepatitis C treated by long-term, low-dose PEG-IFNα-2a
- Source :
- Digestive diseases (Basel, Switzerland). 30(6)
- Publication Year :
- 2012
-
Abstract
- Objective: Increasing evidence suggests the efficacy of maintenance therapy with interferon (IFN) for chronic hepatitis C (CHC) in reducing the risk of hepatocellular carcinoma (HCC). The aim of this study was to determine clinical characteristics on the risk of occurrence of HCC in CHC patients receiving maintenance IFN therapy. Methods: A total of 55 patients were treated in a single center with PEG-IFNα-2a monotherapy for CHC and evaluated for variables predictive of the occurrence of HCC. Results: The cumulative incidences of HCC were 0.092, 0.117 and 0.161 at 3, 5 and 7 years, respectively. Serum ALT level (>40 IU/l) in the 6th month after commencement of IFN therapy and BMI >25 were associated with shorter time-to-HCC emergence using multivariate analysis (relative risk 16.034, p = 0.01 for ALT >40 IU/l; relative risk 6.020, p = 0.026 for BMI >25, respectively). The IL28B SNP was extracted as a significant factor for the occurrence of HCC. Conclusions: Maintenance therapy with the use of long-term low-dose PEG-IFNα-2a is effective for preventing HCC occurrence irrespective of the IL28B SNP, at least for a subset of CHC patients. The initial response of serum ALT levels and BMI provides a prognostic value for determining the risk of developing HCC later in life.
- Subjects :
- Adult
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
Time Factors
Kaplan-Meier Estimate
Gastroenterology
Antiviral Agents
Polymorphism, Single Nucleotide
Body Mass Index
Maintenance Chemotherapy
Polyethylene Glycols
Maintenance therapy
Interferon
Peg ifnα
Risk Factors
Internal medicine
medicine
Carcinoma
Humans
Aged
Proportional Hazards Models
Retrospective Studies
business.industry
Interleukins
Low dose
Liver Neoplasms
Interferon-alpha
Retrospective cohort study
Alanine Transaminase
General Medicine
Hepatitis C
Hepatitis C, Chronic
Middle Aged
medicine.disease
Recombinant Proteins
Hepatocellular carcinoma
Immunology
Multivariate Analysis
RNA, Viral
Female
Interferons
alpha-Fetoproteins
business
medicine.drug
Subjects
Details
- ISSN :
- 14219875
- Volume :
- 30
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Digestive diseases (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....2b41b21e8a5758516e2d30d1027e0c63