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Can Early Aggressive Administration of Fresh Frozen Plasma Improve Outcomes in Patients with Severe Blunt Trauma?--A Report by the Japanese Association for the Surgery of Trauma
- Source :
- Shock (Augusta, Ga.)
- Publication Year :
- 2016
-
Abstract
- Background: This study investigated the effect of a high ratio of fresh frozen plasma (FFP) to red blood cells (RBCs) within the first 6 and 24 h after admission on mortality in patients with severe, blunt trauma. Methods: This retrospective observational study included 189 blunt trauma patients with an Injury Severity Score (ISS) ≥16 requiring RBC transfusions within the first 24 h. Receiver operating characteristic (ROC) curve analysis was performed to calculate cut-off values of the FFP/RBC ratio for outcome. The patients were then divided into two groups according to the cut-off value. Patient survival was compared between groups using propensity score matching (PSM). Results: The area under the ROC curve was 0.57, and the FFP/RBC ratio was 1.0 at maximum sensitivity (0.57) and specificity (0.67). All patients were then divided into two groups (FFP/RBC ratio ≥1 or
- Subjects :
- Adult
Male
medicine.medical_specialty
Blood transfusion
FFP
medicine.medical_treatment
fresh frozen plasma
Blood Component Transfusion
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
Wounds, Nonpenetrating
Clinical Science Aspects
03 medical and health sciences
Plasma
0302 clinical medicine
Blunt
Injury Severity Score
Trauma Centers
medicine
Humans
propensity score
Aged
Proportional Hazards Models
Retrospective Studies
blunt trauma
business.industry
030208 emergency & critical care medicine
Retrospective cohort study
Middle Aged
Surgery
Blunt trauma
Propensity score matching
Emergency Medicine
Female
Fresh frozen plasma
business
Erythrocyte Transfusion
Subjects
Details
- ISSN :
- 15400514
- Volume :
- 45
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Shock (Augusta, Ga.)
- Accession number :
- edsair.doi.dedup.....2b2ceefe6882e2ee786955db4461e48a