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Artificial lungs––Where are we going with the lung replacement therapy?
- Source :
- Artificial Organs
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Lung transplantation may be a final destination therapy in lung failure, but limited donor organ availability creates a need for alternative management, including artificial lung technology. This invited review discusses ongoing developments and future research pathways for respiratory assist devices and tissue engineering to treat advanced and refractory lung disease. An overview is also given on the aftermath of the coronavirus disease 2019 pandemic and lessons learned as the world comes out of this situation. The first order of business in the future of lung support is solving the problems with existing mechanical devices. Interestingly, challenges identified during the early days of development persist today. These challenges include device-related infection, bleeding, thrombosis, cost, and patient quality of life. The main approaches of the future directions are to repair, restore, replace, or regenerate the lungs. Engineering improvements to hollow fiber membrane gas exchangers are enabling longer term wearable systems and can be used to bridge lung failure patients to transplantation. Progress in the development of microchannel-based devices has provided the concept of biomimetic devices that may even enable intracorporeal implantation. Tissue engineering and cell-based technologies have provided the concept of bioartificial lungs with properties similar to the native organ. Recent progress in artificial lung technologies includes continued advances in both engineering and biology. The final goal is to achieve a truly implantable and durable artificial lung that is applicable to destination therapy.
- Subjects :
- medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
medicine.medical_treatment
0206 medical engineering
LIFE-SUPPORT
Biomedical Engineering
FIBER BUNDLE
Medicine (miscellaneous)
Bioengineering
02 engineering and technology
Oxygenators
030204 cardiovascular system & hematology
extracorporeal life support
BRIDGE
Artificial lung
EXTRACORPOREAL MEMBRANE-OXYGENATION
Biomaterials
Wearable Electronic Devices
03 medical and health sciences
0302 clinical medicine
CO2 REMOVAL
lung transplantation
medicine
Extracorporeal membrane oxygenation
Humans
Lung transplantation
wearable portable lung
Intensive care medicine
artificial lung
biofabricated lung
GOAT FETUSES
Lung
Tissue Engineering
PUMP-LUNG
COVID-19
IN-VITRO
General Medicine
extracorporeal membrane oxygenation
020601 biomedical engineering
SINGLE-CENTER EXPERIENCE
Transplantation
end‐
medicine.anatomical_structure
Biomimetic Devices
Intensive Care, Neonatal
stage lung disease
GAS-EXCHANGE
Destination therapy
Subjects
Details
- Language :
- English
- ISSN :
- 15251594 and 0160564X
- Database :
- OpenAIRE
- Journal :
- Artificial Organs
- Accession number :
- edsair.doi.dedup.....2b29d396f440c4c6a062f7f59cda5798
- Full Text :
- https://doi.org/10.1111/aor.13801