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High Expression of Sp1 is Associated with Recurrence of Meningioma
- Source :
- World Neurosurgery. 149:e1056-e1060
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Meningioma has the second highest incidence among primary intracranial tumors. There is no effective treatment or targeted therapy for meningioma except excision and radiotherapy. Sp1 (specificity protein 1) is a transcription factor that regulates tumor growth, but the literature describing the relationship between Sp1 and meningioma is scarce. The purpose of this study was to investigate the relationship between Sp1 expression and the clinicopathological parameters in meningioma by immunohistochemical staining.We collected samples from 74 patients from 2008-2012 in Kaohsiung Medical University Hospital, with staging and prognosis of the pathological section of the meningioma.Our results show that Sp1 expression was significantly associated with World Health Organization grade, malignancy, and recurrence in patients with meningioma.High expression of Sp1 in patients with meningioma was linked to poor prognosis of recurrence-free time. Therefore Sp1 may be a candidate biomarker of prognosis and therapy target in meningioma.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Sp1 Transcription Factor
medicine.medical_treatment
Kaplan-Meier Estimate
Malignancy
Targeted therapy
Cohort Studies
Meningioma
03 medical and health sciences
0302 clinical medicine
Internal medicine
Biomarkers, Tumor
otorhinolaryngologic diseases
medicine
Humans
RNA, Messenger
neoplasms
Pathological
Aged
Aged, 80 and over
Brain Neoplasms
business.industry
Incidence (epidemiology)
Middle Aged
Prognosis
medicine.disease
Survival Analysis
nervous system diseases
Radiation therapy
030220 oncology & carcinogenesis
Biomarker (medicine)
Immunohistochemistry
Female
Surgery
Neurology (clinical)
Neoplasm Recurrence, Local
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18788750
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- World Neurosurgery
- Accession number :
- edsair.doi.dedup.....2b22e3d8b4737928d5dfe63aa0057c8d